{"title":"Anti-Aging \u0026 Longevity Peptides","description":"","products":[{"product_id":"bpc-157-tb-500","title":"BPC-157 + TB-500 - Wolverine Stack","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 auto;padding:0 24px}.pp-pdp .pp-kick{color:var(--tl);font-size:12px;letter-spacing:2.16px;text-transform:uppercase;font-weight:600;margin:0 0 12px}.pp-pdp .pp-sec{padding:56px 0}.pp-pdp .pp-alt{background:var(--sf)}.pp-pdp .pp-sec h2{font-size:30px}.pp-pdp .pp-prose 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.pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eInjury recovery — two compounds, one vial\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e500mcg of each, daily\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e20 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eThe Wolverine Stack is BPC-157 and TB-500 supplied together — 10mg of each in a single vial.\u003c\/p\u003e\n\u003cp\u003eIt is the most common pairing in the recovery category. People use it after a specific injury, or through a heavy training block, because the two compounds cover different parts of the repair process rather than doubling up on the same one.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eBPC-157 10mg + TB-500 10mg in one vial\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eTendon, ligament and muscle injury recovery\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e500mcg of each, once daily, for 4–8 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eRepair needs two things: blood getting to the damaged area, and repair cells physically moving into it.\u003c\/p\u003e\n\u003cp\u003eBPC-157 is associated with the first — new blood vessel growth into tissue that normally has a poor supply. TB-500 is associated with the second — the internal machinery cells use to migrate.\u003c\/p\u003e\n\u003cp\u003eThe two do not share a pathway, which is the entire logic of the pairing. No controlled study of the combination itself has been published; the evidence sits with each compound separately.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-bpc-157.png?v=1785967535\" alt=\"BPC-157 molecular structure diagram — a constituent of the BPC-157 + TB-500 stack\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eThe rationale for pairing these two compounds is mechanistic separation, not additive potency. They intervene at different points in the tissue repair sequence and, on current evidence, share no common pathway.\u003c\/p\u003e\n\u003cp\u003eBPC-157 is a 15-residue fragment of a protein isolated from human gastric juice. No single high-affinity receptor has been identified for it. Its described actions are extracellular and vascular: Hsieh et al. (Journal of Molecular Medicine, 2017) associated its pro-angiogenic activity with activation and upregulation of VEGFR2 and downstream Akt–eNOS signalling, with the effect attenuated by VEGFR2 blockade. A second body of work describes bidirectional modulation of the nitric oxide system, with Hsieh et al. (Scientific Reports, 2020) reporting effects on vasomotor tone through a Src–caveolin-1–eNOS pathway. In connective tissue, Chang et al. (Journal of Applied Physiology, 2011) reported increased tendon fibroblast outgrowth, survival and migration in vitro. The functional theme is vascular supply and the extracellular signalling environment.\u003c\/p\u003e\n\u003cp\u003eTB-500 is based on thymosin beta-4, the principal G-actin sequestering peptide in mammalian cells. It binds actin monomer in a 1:1 complex and holds it unpolymerised, creating a reservoir that permits rapid, localised F-actin polymerisation at the migrating cell's leading edge. The actin-binding activity localises to the LKKTETQ motif. Malinda et al. (Journal of Investigative Dermatology, 1999) reported accelerated dermal repair in rodent models; Bock-Marquette et al. (Nature, 2004) described a separate pathway through integrin-linked kinase activation in cardiac tissue. A further mechanism operates through liberation of the N-terminal tetrapeptide Ac-SDKP by prolyl oligopeptidase and meprin-α, which carries independent anti-fibrotic activity. The functional theme here is intracellular: cytoskeletal remodelling and cell motility.\u003c\/p\u003e\n\u003cp\u003eOne compound addresses whether cells can reach the site and whether it is perfused; the other addresses the machinery cells use to move. That non-overlap is the entire basis of the pairing.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eTwo mechanisms, no overlap\u003c\/h3\u003e\n\u003cp\u003eOne targets blood supply to the injury, the other targets how repair cells move into it.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eBoth evidence bases are animal-stage\u003c\/h3\u003e\n\u003cp\u003eEach compound has substantial preclinical work behind it and limited human trial data.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eNo study of the combination\u003c\/h3\u003e\n\u003cp\u003eThe pairing is reasoned from the separate mechanisms, not from a trial of the two together.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eConvenient single vial\u003c\/h3\u003e\n\u003cp\u003eOne reconstitution, one injection, both compounds at the standard dose.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eWolverine Stack — BPC-157 10mg + TB-500 10mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 500mcg BPC-157 + 500mcg TB-500.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e250mcg each daily\u003c\/td\u003e\n\u003ctd\u003e5 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e500mcg each daily\u003c\/td\u003e\n\u003ctd\u003e10 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 20 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once daily. For acute injury, twice daily — morning and evening.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 4 to 8 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen or inject near the area of concern\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eIs there research on the combination itself?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo controlled study of BPC-157 and TB-500 administered together has been published. The evidence base consists of separate preclinical work on each compound. The pairing is a research convention grounded in mechanistic non-overlap, not a validated protocol, and should be described as such.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy are these two compounds paired?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eTheir mechanisms do not intersect. BPC-157's described actions are extracellular and vascular — VEGFR2-associated angiogenic signalling and modulation of nitric oxide. TB-500 acts intracellularly on the actin cytoskeleton, controlling the machinery of cell migration. Pairing them addresses two different constraints on tissue repair.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eDo I need to mix the two compounds separately?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo. The Wolverine Stack is supplied as a single pre-mixed vial containing 10mg of each compound, so one reconstitution covers both. Add the bacteriostatic water to the vial as supplied and follow the mixing steps above.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is it called the Wolverine Stack?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIt is a colloquial name that circulated in research and forum communities, referring to the fictional character's rapid tissue repair. It carries no scientific meaning and implies nothing about the strength of the underlying evidence, which is preclinical.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by independent HPLC at Bioindustrial Services in Boksburg, and the assay covers both compounds in the vial. We do not rely on the manufacturer's own certificate alone. The assay reports for the batches you receive are available on request, and our full testing protocol is set out at \u003ca href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \u003ca href=\"\/pages\/delivery-process\"\u003eDelivery Process\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eCan I return an order?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnder the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out in our \u003ca href=\"\/pages\/return-refund-policy\"\u003eRefund Policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/recovery-repair-peptides\"\u003eAlso in Recovery \u0026amp; Tissue Repair\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/recovery-peptide-stack\"\u003eRecovery Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/performance-recovery-peptide-stack\"\u003ePerformance Recovery Peptide Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"Is there research on the combination itself?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No controlled study of BPC-157 and TB-500 administered together has been published. The evidence base consists of separate preclinical work on each compound. The pairing is a research convention grounded in mechanistic non-overlap, not a validated protocol, and should be described as such.\"}},{\"@type\":\"Question\",\"name\":\"Why are these two compounds paired?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Their mechanisms do not intersect. BPC-157's described actions are extracellular and vascular, involving VEGFR2-associated angiogenic signalling and modulation of nitric oxide. TB-500 acts intracellularly on the actin cytoskeleton, controlling the machinery of cell migration. Pairing them addresses two different constraints on tissue repair.\"}},{\"@type\":\"Question\",\"name\":\"Do I need to mix the two compounds separately?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No. The Wolverine Stack is supplied as a single pre-mixed vial containing 10mg of each compound, so one reconstitution covers both. Add the bacteriostatic water to the vial as supplied and follow the mixing steps above.\"}},{\"@type\":\"Question\",\"name\":\"Why is it called the Wolverine Stack?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"It is a colloquial name that circulated in research and forum communities, referring to the fictional character's rapid tissue repair. It carries no scientific meaning and implies nothing about the strength of the underlying evidence, which is preclinical.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by independent HPLC at Bioindustrial Services in Boksburg, and the assay covers both compounds in the vial. We do not rely on the manufacturer's own certificate alone. The assay reports for the batches you receive are available on request, and our full testing protocol is set out at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"Can I return an order?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Under the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172130005215,"sku":null,"price":79.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/BPC-157___TB-500_1.png?v=1778674591"},{"product_id":"cjc-1295-w-dac","title":"CJC‑1295 w\/o DAC 5 mg + IPA 5 mg","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 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.pp-tldr{list-style:none;margin:18px 0 0;padding:16px 0 0;border-top:1px solid var(--ln)}.pp-pdp .pp-tldr li{display:flex;gap:14px;padding:6px 0;font-size:14.5px;color:var(--mut)}.pp-pdp .pp-tldr b{color:var(--nv);flex:0 0 148px}.pp-pdp .pp-card h3{font-size:15.5px;margin:0 0 8px;color:var(--nv);line-height:1.3}.pp-pdp .pp-more{margin-top:24px;max-width:900px}.pp-pdp .pp-more .pp-ab p{margin-bottom:12px}.pp-pdp .pp-dose{width:100%;border-collapse:collapse;margin:0 0 16px}.pp-pdp .pp-dose th,.pp-pdp .pp-dose td{text-align:left;padding:11px 14px;border-bottom:1px solid var(--ln);font-size:14.5px;color:var(--mut)}.pp-pdp .pp-dose th{background:var(--nv);color:#fff;font-size:11.5px;letter-spacing:1.2px;text-transform:uppercase;font-weight:700}.pp-pdp .pp-dose td:first-child{font-weight:700;color:var(--nv);white-space:nowrap}.pp-pdp .pp-step{counter-reset:s;list-style:none;padding:0;margin:0 0 18px}.pp-pdp .pp-step li{position:relative;padding:0 0 11px 34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eGrowth hormone support — one injection a week\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e1mg once weekly\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e5 weeks per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eCJC-1295 with DAC is a modified version of the signal your brain uses to tell the pituitary to release growth hormone.\u003c\/p\u003e\n\u003cp\u003eIts defining feature is duration. Once injected, it clips onto a protein in your blood and stays active for days rather than minutes. That is why it is a once-weekly injection while most peptides in this category are daily.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA long-acting analogue of growth hormone-releasing hormone\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eRaising the body's own growth hormone and IGF-1 output\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e1mg once weekly, same day each week, 8–16 weeks then a 4-week break\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eYour pituitary already releases growth hormone in pulses. CJC-1295 pushes on that existing system rather than replacing it — so your body's own feedback controls still apply.\u003c\/p\u003e\n\u003cp\u003eNatural GHRH is destroyed in the bloodstream within minutes. Four small changes to the molecule block the enzymes that break it down.\u003c\/p\u003e\n\u003cp\u003eThe DAC part is the clever bit: it forms a permanent bond with albumin, the most abundant protein in blood. That makes the whole package too big for the kidneys to filter out, stretching its life from minutes to days.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-cjc-1295-w-dac.png?v=1785967669\" alt=\"CJC-1295 with DAC molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eCJC-1295 with DAC is built on GRF(1-29), the N-terminal fragment of human growth hormone-releasing hormone that retains the full receptor activity of the 44-residue native peptide. Four positions are substituted — D-Ala at 2, Gln at 8, Ala at 15 and Leu at 27 — each closing a route of degradation. The D-Ala2 substitution matters most: native GHRH is cleaved between residues 2 and 3 by dipeptidyl peptidase-IV within minutes of entering plasma, and the D-amino acid renders that bond unrecognisable. The other substitutions reduce trypsin cleavage and asparagine deamidation.\u003c\/p\u003e\n\u003cp\u003eThe Drug Affinity Complex is the more distinctive modification. A lysine is appended at position 30 and its side chain carries a maleimidopropionyl group. Maleimide reacts selectively with free thiols, and the only abundant free thiol in plasma is Cys34 of serum albumin. The peptide therefore forms a covalent thioether bond with albumin in situ, producing a conjugate too large for glomerular filtration and largely shielded from peptidase access. Circulating half-life is measured in days rather than minutes.\u003c\/p\u003e\n\u003cp\u003eReceptor engagement is conventional. The peptide binds GHRHR, a class B G protein-coupled receptor on anterior pituitary somatotrophs, coupling through Gs to adenylyl cyclase. The cAMP rise activates protein kinase A, which phosphorylates CREB and drives Pit-1-dependent GH gene transcription alongside calcium-mediated release of stored granules. Hepatic GH receptor signalling then raises IGF-1.\u003c\/p\u003e\n\u003cp\u003eTwo contrasts define its position. Against CJC-1295 without DAC, which shares the substitutions but lacks the linker, the difference is purely pharmacokinetic — a discrete pulse against a sustained elevation of baseline. Against ghrelin mimetics such as Ipamorelin, acting at GHS-R1a, the receptor and pathway differ entirely. Teichman et al. (J Clin Endocrinol Metab, 2006) reported sustained GH and IGF-1 elevation after single subcutaneous doses in healthy adults; Ionescu and Frohman (J Clin Endocrinol Metab, 2006) found endogenous pulsatility persisted despite continuous receptor stimulation.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eOne injection covers a week\u003c\/h3\u003e\n\u003cp\u003eBonding to blood albumin extends its half-life to roughly 6–8 days.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eUses your own GH pulses\u003c\/h3\u003e\n\u003cp\u003eIt amplifies the pituitary's natural pulsatile release rather than imposing a flat, constant level.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eSustained IGF-1 rise in humans\u003c\/h3\u003e\n\u003cp\u003eA published clinical study reported sustained growth hormone and IGF-1 elevation after single doses.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003ePulsing is preserved\u003c\/h3\u003e\n\u003cp\u003eHuman work found the natural pulse pattern persisted rather than flattening out under continuous stimulation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eCJC-1295 w DAC 5mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 250mcg of CJC-1295 w DAC.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e500mcg once weekly\u003c\/td\u003e\n\u003ctd\u003e20 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e1mg once weekly\u003c\/td\u003e\n\u003ctd\u003e40 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 5 weeks\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"pp-warn\"\u003e\u003cp\u003eCJC-1295 w DAC has a half-life of 6 to 8 days. Inject once on the same day each week. Do not inject daily.\u003c\/p\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once weekly on the same day each week. Inject on an empty stomach where possible.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 8 to 16 weeks, then take a 4-week break.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the DAC in CJC-1295 with DAC?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eDAC stands for Drug Affinity Complex — a maleimidopropionyl group on a C-terminal lysine that reacts with the free thiol of Cys34 on serum albumin. The resulting covalent conjugate is too large for renal filtration, which is why the compound persists for days rather than minutes.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does it differ from CJC-1295 without DAC?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eBoth share the same four amino acid substitutions on the GRF(1-29) backbone. Only the DAC version carries the albumin-binding linker. Without it, the peptide is cleared rapidly and produces a discrete pulse of GH release; with it, receptor stimulation is continuous and baseline GH and IGF-1 are elevated across days.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does it differ from Ipamorelin?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eDifferent receptor entirely. CJC-1295 acts at the GHRH receptor on pituitary somatotrophs. Ipamorelin is a ghrelin mimetic acting at GHS-R1a, which stimulates GH release through a separate pathway and reduces somatostatin tone. The two are studied together in research models precisely because the mechanisms are independent.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat has it been studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003ePublished human pharmacology is limited to the 2006 JCEM papers, which examined GH and IGF-1 secretion kinetics in healthy adults. Later research interest has centred on the somatotropic axis, body composition and sleep architecture in preclinical settings.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our \u003ca href=\"\/pages\/quality-standards\"\u003equality standards page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our \u003ca href=\"\/pages\/delivery-process\"\u003edelivery process page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the returns policy?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials in original condition may be returned within the stated window; full terms are in our \u003ca href=\"\/pages\/return-refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/lean-muscle-growth-peptides\"\u003eAlso in Lean Muscle \u0026amp; Growth Hormone\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/tesamorelin\"\u003eTesamorelin\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/mots-c\"\u003eMOTS-C\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/gh-optimisation-peptide-stack\"\u003eGH Optimisation Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/lean-growth-peptide-stack\"\u003eLean Growth Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/performance-recovery-peptide-stack\"\u003ePerformance Recovery Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/deep-sleep-peptide-stack\"\u003eDeep Sleep Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What is the DAC in CJC-1295 with DAC?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"DAC stands for Drug Affinity Complex — a maleimidopropionyl group on a C-terminal lysine that reacts with the free thiol of Cys34 on serum albumin. The resulting covalent conjugate is too large for renal filtration, which is why the compound persists for days rather than minutes.\"}},{\"@type\":\"Question\",\"name\":\"How does it differ from CJC-1295 without DAC?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Both share the same four amino acid substitutions on the GRF(1-29) backbone. Only the DAC version carries the albumin-binding linker. Without it, the peptide is cleared rapidly and produces a discrete pulse of GH release; with it, receptor stimulation is continuous and baseline GH and IGF-1 are elevated across days.\"}},{\"@type\":\"Question\",\"name\":\"How does it differ from Ipamorelin?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Different receptor entirely. CJC-1295 acts at the GHRH receptor on pituitary somatotrophs. Ipamorelin is a ghrelin mimetic acting at GHS-R1a, which stimulates GH release through a separate pathway and reduces somatostatin tone. The two are studied together in research models precisely because the mechanisms are independent.\"}},{\"@type\":\"Question\",\"name\":\"What has it been studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Published human pharmacology is limited to the 2006 JCEM papers, which examined GH and IGF-1 secretion kinetics in healthy adults. Subsequent research interest has centred on the somatotropic axis, body composition and sleep architecture in preclinical and observational settings.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our quality standards page at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our delivery process page at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"What is the returns policy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Unopened vials in original condition may be returned within the stated window; full terms are in our refund policy at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172130627807,"sku":null,"price":59.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/CJC_1295w_oDAC5mg_IPA5mg.png?v=1779265514"},{"product_id":"ghk-cu","title":"GHK-CU","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 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@media(max-width:520px){.pp-pdp .pp-facts .pp-in{grid-template-columns:1fr}}.pp-pdp .pp-ov{border-left:4px solid var(--tl);background:var(--sf);border-radius:0 12px 12px 0;padding:26px 28px;max-width:900px}.pp-pdp .pp-ov p{font-size:16px;color:var(--ink)}.pp-pdp .pp-tldr{list-style:none;margin:18px 0 0;padding:16px 0 0;border-top:1px solid var(--ln)}.pp-pdp .pp-tldr li{display:flex;gap:14px;padding:6px 0;font-size:14.5px;color:var(--mut)}.pp-pdp .pp-tldr b{color:var(--nv);flex:0 0 148px}.pp-pdp .pp-card h3{font-size:15.5px;margin:0 0 8px;color:var(--nv);line-height:1.3}.pp-pdp .pp-more{margin-top:24px;max-width:900px}.pp-pdp .pp-more .pp-ab p{margin-bottom:12px}.pp-pdp .pp-dose{width:100%;border-collapse:collapse;margin:0 0 16px}.pp-pdp .pp-dose th,.pp-pdp .pp-dose td{text-align:left;padding:11px 14px;border-bottom:1px solid var(--ln);font-size:14.5px;color:var(--mut)}.pp-pdp .pp-dose th{background:var(--nv);color:#fff;font-size:11.5px;letter-spacing:1.2px;text-transform:uppercase;font-weight:700}.pp-pdp .pp-dose td:first-child{font-weight:700;color:var(--nv);white-space:nowrap}.pp-pdp .pp-step{counter-reset:s;list-style:none;padding:0;margin:0 0 18px}.pp-pdp .pp-step li{position:relative;padding:0 0 11px 34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eSkin firmness, tone and repair\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e2mg daily\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e50 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eGHK-Cu is a very short peptide — three amino acids — bound to copper. Your body makes it naturally, and levels drop substantially with age. That decline is what first made it interesting.\u003c\/p\u003e\n\u003cp\u003eIt is the best-known peptide for skin: firmness, tone, texture and scarring. It is also used for hair and general tissue repair.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA copper-bound tripeptide (Gly-His-Lys) the body produces naturally\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eSkin firmness and tone, scarring, hair, tissue repair\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e2mg once daily, morning, for 8–12 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eCopper is not optional for skin structure. The enzyme that cross-links collagen and elastin into mature, springy fibres cannot work without it.\u003c\/p\u003e\n\u003cp\u003eGHK-Cu's job is delivery. It picks copper up from blood proteins and hands it over to the cells and enzymes that need it — it does not lock it away.\u003c\/p\u003e\n\u003cp\u003eThat is the difference between GHK-Cu and either a copper supplement or a copper-free peptide. It also influences a wide set of genes involved in matrix turnover and antioxidant defence.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-ghk-cu.png?v=1785967535\" alt=\"GHK-Cu molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eGHK is a tripeptide — glycine, histidine, lysine — isolated from human plasma by Pickart and colleagues in the early 1970s and later identified as a fragment released during proteolysis of collagen and other matrix proteins. Its plasma concentration falls substantially with age, the observation that first prompted interest in it as an endogenous repair signal.\u003c\/p\u003e\n\u003cp\u003eThe chemistry that defines it is copper coordination. The N-terminal amine, the deprotonated amide nitrogen of the first peptide bond and the imidazole nitrogen of histidine form a square-planar chelation site for Cu2+ with very high affinity — comparable to the copper-binding site of serum albumin. GHK therefore does not sequester copper inertly; it exchanges it, accepting Cu2+ from albumin and delivering it to cellular transporters and cuproenzymes. That is why the complex behaves differently from either free copper salts or a copper-free peptide.\u003c\/p\u003e\n\u003cp\u003eThe delivery role connects directly to matrix biology. Lysyl oxidase, the enzyme that cross-links collagen and elastin fibrils into mature load-bearing structures, is copper-dependent; so are superoxide dismutase 1 and cytochrome c oxidase. Copper availability is therefore rate-limiting for matrix maturation rather than merely for matrix synthesis — the distinction between GHK-Cu and peptides that stimulate collagen transcription alone.\u003c\/p\u003e\n\u003cp\u003eBeyond copper transport, GHK-Cu shows broad transcriptional activity. Pickart and Margolina (Int J Mol Sci, 2018), drawing on Broad Institute Connectivity Map data, reported modulation of expression across a large fraction of human genes, with the pattern favouring tissue remodelling: increased collagen I, decorin and other small proteoglycans, alongside coordinated changes in matrix metalloproteinases and their TIMP inhibitors. That combination is characteristic of controlled turnover rather than simple accumulation. Pickart, Vasquez-Soltero and Margolina (BioMed Research International, 2015) reviewed the same pathways in skin regeneration, including antioxidant and anti-inflammatory gene modulation.\u003c\/p\u003e\n\u003cp\u003eAmong the skin-directed compounds on this site, GHK-Cu occupies the copper and matrix-maturation position. BPC-157 and TB-500, its partners in the GLOW and KLOW blends, act on angiogenesis and actin dynamics — adjacent but mechanistically separate.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eYour natural level falls with age\u003c\/h3\u003e\n\u003cp\u003eGHK is present in human plasma and declines substantially over the decades — the original reason for research interest.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eDelivers copper rather than storing it\u003c\/h3\u003e\n\u003cp\u003eIt binds copper about as tightly as your blood's main carrier protein, then releases it to cells.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eSupports collagen cross-linking\u003c\/h3\u003e\n\u003cp\u003eThe enzyme that turns new collagen and elastin into mature fibre is copper-dependent.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eBroad effect on repair genes\u003c\/h3\u003e\n\u003cp\u003ePublished gene-expression work reports it shifts a wide set of matrix and antioxidant genes toward controlled repair.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eGHK-Cu 100mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 5mg of GHK-Cu.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e1mg daily\u003c\/td\u003e\n\u003ctd\u003e2 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e2mg daily\u003c\/td\u003e\n\u003ctd\u003e4 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 50 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once daily, morning preferred.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 8 to 12 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is the copper part significant?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eBecause the peptide's principal characterised function is copper transport. GHK binds Cu2+ tightly enough to accept it from albumin but reversibly enough to pass it on to cellular transporters and copper-dependent enzymes. A copper-free GHK preparation is a different research material with a different activity profile.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is the reconstituted solution blue?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eThe colour comes from d-d electronic transitions of the coordinated copper(II) ion. It is expected, and its presence is a rough indication that the complex remains intact. Loss of colour or a marked colour shift suggests dissociation or degradation.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does GHK-Cu differ from BPC-157 and TB-500?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eDifferent mechanisms entirely. GHK-Cu delivers copper to matrix enzymes and modulates matrix gene expression. BPC-157 is studied chiefly for angiogenic and growth factor signalling; TB-500 for actin sequestration and cell migration. They appear together in the GLOW and KLOW blends because the pathways are complementary rather than overlapping.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is it studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003ePublished research centres on extracellular matrix remodelling, wound and tissue repair models, antioxidant and anti-inflammatory gene expression, and dermatological applications. Pickart's laboratory produced the majority of the foundational literature.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our \u003ca href=\"\/pages\/quality-standards\"\u003equality standards page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our \u003ca href=\"\/pages\/delivery-process\"\u003edelivery process page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eCan I return an order?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnder the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out in our \u003ca href=\"\/pages\/return-refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/skin-peptides\"\u003eAlso in Skin, Collagen \u0026amp; Cellular Renewal\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/glow\"\u003eGLOW\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/klow\"\u003eKLOW\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/glutathione\"\u003eGlutathione\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin Recovery Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin \u0026amp; Anti-Ageing Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"Why is the copper part significant?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Because the peptide's principal characterised function is copper transport. GHK binds Cu2+ tightly enough to accept it from albumin but reversibly enough to pass it on to cellular transporters and copper-dependent enzymes. A copper-free GHK preparation is a different research material with a different activity profile.\"}},{\"@type\":\"Question\",\"name\":\"Why is the reconstituted solution blue?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"The colour comes from d-d electronic transitions of the coordinated copper(II) ion. It is expected, and its presence is a rough indication that the complex remains intact. Loss of colour or a marked colour shift suggests dissociation or degradation.\"}},{\"@type\":\"Question\",\"name\":\"How does GHK-Cu differ from BPC-157 and TB-500?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Different mechanisms entirely. GHK-Cu delivers copper to matrix enzymes and modulates matrix gene expression. BPC-157 is studied chiefly for angiogenic and growth factor signalling; TB-500 for actin sequestration and cell migration. They appear together in the GLOW and KLOW blends because the pathways are complementary rather than overlapping.\"}},{\"@type\":\"Question\",\"name\":\"What is it studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Published research centres on extracellular matrix remodelling, wound and tissue repair models, antioxidant and anti-inflammatory gene expression, and dermatological applications. Pickart's laboratory produced the majority of the foundational literature.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our quality standards page at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our delivery process page at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"Can I return an order?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Under the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"Purist Peptides","offers":[{"title":"Default Title","offer_id":49172132004063,"sku":null,"price":54.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/GHK-CU_379beee5-6401-4db3-9d64-8ce24a44d9aa.png?v=1778674595"},{"product_id":"glutathione","title":"Glutathione","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 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.pp-tldr{list-style:none;margin:18px 0 0;padding:16px 0 0;border-top:1px solid var(--ln)}.pp-pdp .pp-tldr li{display:flex;gap:14px;padding:6px 0;font-size:14.5px;color:var(--mut)}.pp-pdp .pp-tldr b{color:var(--nv);flex:0 0 148px}.pp-pdp .pp-card h3{font-size:15.5px;margin:0 0 8px;color:var(--nv);line-height:1.3}.pp-pdp .pp-more{margin-top:24px;max-width:900px}.pp-pdp .pp-more .pp-ab p{margin-bottom:12px}.pp-pdp .pp-dose{width:100%;border-collapse:collapse;margin:0 0 16px}.pp-pdp .pp-dose th,.pp-pdp .pp-dose td{text-align:left;padding:11px 14px;border-bottom:1px solid var(--ln);font-size:14.5px;color:var(--mut)}.pp-pdp .pp-dose th{background:var(--nv);color:#fff;font-size:11.5px;letter-spacing:1.2px;text-transform:uppercase;font-weight:700}.pp-pdp .pp-dose td:first-child{font-weight:700;color:var(--nv);white-space:nowrap}.pp-pdp .pp-step{counter-reset:s;list-style:none;padding:0;margin:0 0 18px}.pp-pdp .pp-step li{position:relative;padding:0 0 11px 34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eAntioxidant defence and skin brightness\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e600mg, 2–3x weekly\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eapprox 8 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eGlutathione is your body's main internal antioxidant — a three-amino-acid molecule your liver produces in large amounts and uses to neutralise damage and clear toxins.\u003c\/p\u003e\n\u003cp\u003eIt is used for antioxidant support, liver load, general recovery, and — the reason most people buy it — skin brightening and evenness of tone.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eThe body's principal internal antioxidant, a tripeptide\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eAntioxidant support, detoxification load, skin brightness and tone\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e600mg per session, 2–3 times per week, 4–8 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eGlutathione neutralises damaging molecules by sacrificing part of itself, then gets recycled back to its active form. That cycle is running constantly in every cell.\u003c\/p\u003e\n\u003cp\u003eIt is also the body's main handle for grabbing toxins and drug by-products so they can be excreted — most of the liver's clearance work goes through it.\u003c\/p\u003e\n\u003cp\u003eThe skin effect comes from a separate action: it interferes with the enzyme that produces dark pigment and shifts pigment production toward the lighter type.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-glutathione.png?v=1785967535\" alt=\"Glutathione molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eThe structural detail that governs glutathione's biology is the gamma linkage. The bond to cysteine forms from the side-chain gamma-carboxyl of glutamate rather than its alpha-carboxyl, and conventional aminopeptidases cannot recognise it. The only enzyme that cleaves it is gamma-glutamyl transpeptidase, on the external face of the plasma membrane. Intracellular glutathione is therefore protected from proteolysis, while extracellular glutathione must be dismantled to its constituent amino acids and reassembled inside the cell — the gamma-glutamyl cycle described by Meister and Anderson (Annu Rev Biochem, 1983). Hence millimolar cytosolic concentrations against low micromolar in plasma.\u003c\/p\u003e\n\u003cp\u003eSynthesis proceeds in two ATP-dependent steps. Glutamate-cysteine ligase, a heterodimer of catalytic and modifier subunits, forms the gamma-glutamylcysteine bond; glutathione synthetase then adds glycine. The first step is rate-limiting and feedback-inhibited by glutathione itself, with cysteine availability the usual substrate constraint. Transcription of both ligase subunits is under NRF2 control through antioxidant response elements, coupling glutathione capacity to oxidative and electrophilic stress (Lu, Biochim Biophys Acta, 2013).\u003c\/p\u003e\n\u003cp\u003eFunctionally the molecule works through its cysteine thiol. Glutathione peroxidases use it to reduce hydrogen peroxide and lipid hydroperoxides, generating the disulfide GSSG, which glutathione reductase reduces again at the cost of NADPH — a direct dependency on pentose phosphate pathway flux. Glutathione S-transferases conjugate it to electrophilic xenobiotics, initiating the mercapturic acid excretion pathway. Reversible S-glutathionylation of protein cysteines acts as a redox post-translational modification, reversed by glutaredoxins. Glutathione also recycles ascorbate and alpha-tocopherol and is the principal intracellular reservoir of cysteine.\u003c\/p\u003e\n\u003cp\u003eIts relevance to pigment research runs through a separate route: glutathione inhibits tyrosinase, partly by coordinating the copper ions at the enzyme's active site, and its thiol reacts with dopaquinone to divert melanogenesis from eumelanin toward pheomelanin. Arjinpathana and Asawanonda (J Dermatolog Treat, 2012) examined oral glutathione against placebo in a randomised, double-blind trial measuring melanin index. Adjacent compounds differ: N-acetylcysteine is a cysteine precursor acting upstream of synthesis, and GSSG is the oxidised dimer rather than the active thiol.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eYour cells hold a thousand times more than your blood\u003c\/h3\u003e\n\u003cp\u003eConcentrations are millimolar inside cells versus low micromolar in plasma — supply is an intracellular problem.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eRecycled, not used up once\u003c\/h3\u003e\n\u003cp\u003eIt is continuously restored to its active form after neutralising damage.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eProduction is self-limiting\u003c\/h3\u003e\n\u003cp\u003eThe rate-limiting enzyme is switched off by glutathione itself, so the body caps its own output.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eShifts pigment production\u003c\/h3\u003e\n\u003cp\u003eIt inhibits tyrosinase and diverts melanin synthesis toward the lighter pigment type — the basis of the skin-brightening use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eGlutathione 1500mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 5ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 5ml of water added, each 1ml (100 units) you draw = 300mg of Glutathione.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e300mg per session, 2 to 3 times per week\u003c\/td\u003e\n\u003ctd\u003e100 units (1ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e600mg per session, 2 to 3 times per week\u003c\/td\u003e\n\u003ctd\u003e100 units x 2 injections (2ml total)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose (3x weekly at 600mg): approx 8 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"pp-warn\"\u003e\u003cp\u003eFor the 600mg dose, split across 2 separate 1ml injections and rotate sites.\u003c\/p\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Any consistent time of day. Rotate injection sites with each dose.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 4 to 8 weeks.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen, thigh, or upper arm\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat does the gamma linkage actually change?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIt makes the molecule resistant to ordinary peptidases. Only gamma-glutamyl transpeptidase, an ectoenzyme on the cell surface, can break it. That single structural feature explains why intracellular glutathione persists at millimolar concentrations while circulating glutathione is rapidly dismantled.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does glutathione differ from N-acetylcysteine?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNAC is a precursor, not a substitute. It supplies cysteine, the rate-limiting substrate for glutamate-cysteine ligase, and acts upstream of glutathione synthesis. Glutathione is the finished tripeptide and the direct cofactor for peroxidase, transferase and glutaredoxin systems.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the difference between GSH and GSSG?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eGSH is the reduced form with a free cysteine thiol — the biologically active species. GSSG is the oxidised dimer, two glutathione molecules joined by a disulfide bond. The ratio between them is a standard readout of intracellular redox state, and glutathione reductase converts GSSG back to GSH using NADPH.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is it studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eResearch contexts include cellular redox buffering, phase II xenobiotic conjugation, protein S-glutathionylation as a signalling modification, hepatic oxidative stress models, and melanogenesis, where it inhibits tyrosinase and shifts melanin composition.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our \u003ca href=\"\/pages\/quality-standards\"\u003equality standards page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our \u003ca href=\"\/pages\/delivery-process\"\u003edelivery process page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the returns policy?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials in original condition may be returned within the stated window; full terms are in our \u003ca href=\"\/pages\/return-refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/skin-peptides\"\u003eAlso in Skin, Collagen \u0026amp; Cellular Renewal\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/glow\"\u003eGLOW\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/nad\"\u003eNAD+\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin \u0026amp; Anti-Ageing Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin Recovery Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What does the gamma linkage actually change?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"It makes the molecule resistant to ordinary peptidases. Only gamma-glutamyl transpeptidase, an ectoenzyme on the cell surface, can break it. That single structural feature explains why intracellular glutathione persists at millimolar concentrations while circulating glutathione is rapidly dismantled.\"}},{\"@type\":\"Question\",\"name\":\"How does glutathione differ from N-acetylcysteine?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"NAC is a precursor, not a substitute. It supplies cysteine, the rate-limiting substrate for glutamate-cysteine ligase, and acts upstream of glutathione synthesis. Glutathione is the finished tripeptide and the direct cofactor for peroxidase, transferase and glutaredoxin systems.\"}},{\"@type\":\"Question\",\"name\":\"What is the difference between GSH and GSSG?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"GSH is the reduced form with a free cysteine thiol — the biologically active species. GSSG is the oxidised dimer, two glutathione molecules joined by a disulfide bond. The ratio between them is a standard readout of intracellular redox state, and glutathione reductase converts GSSG back to GSH using NADPH.\"}},{\"@type\":\"Question\",\"name\":\"What is it studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Research contexts include cellular redox buffering, phase II xenobiotic conjugation, protein S-glutathionylation as a signalling modification, hepatic oxidative stress models, and melanogenesis, where it inhibits tyrosinase and shifts melanin composition.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our quality standards page at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our delivery process page at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"What is the returns policy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Unopened vials in original condition may be returned within the stated window; full terms are in our refund policy at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172134002911,"sku":null,"price":1500.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/Glutathione_1.png?v=1778674599"},{"product_id":"mots-c","title":"MOTS-C 30mg","description":"\u003cp\u003eMOTS-C is a mitochondrial-encoded peptide that originates from mitochondrial DNA rather than nuclear DNA. It is an essential compound in research related to cellular energy regulation and metabolic signaling.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eKey Features:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli data-path-to-node=\"8,0,0\"\u003e\n\u003cb data-path-to-node=\"8,0,0\" data-index-in-node=\"0\"\u003ePhysiological Stress\u003c\/b\u003e: Studies investigate how MOTS-C helps cells adapt to various forms of physiological stress.\u003c\/li\u003e\n\u003cli data-path-to-node=\"8,1,0\"\u003e\n\u003cb data-path-to-node=\"8,1,0\" data-index-in-node=\"0\"\u003eResponse Mechanisms\u003c\/b\u003e: It is used to explore the mechanisms of cellular adaptation, helping researchers understand how cells maintain homeostasis under pressure.\u003c\/li\u003e\n\u003cli data-path-to-node=\"8,2,0\"\u003e\n\u003cb data-path-to-node=\"8,2,0\" data-index-in-node=\"0\"\u003eAdaptation Pathways\u003c\/b\u003e: The peptide serves as a key subject in research involving the pathways through which mitochondria signal for cellular protection and adaptation.\u003c\/li\u003e\n\u003cli data-path-to-node=\"8,2,0\"\u003e\n\u003cb data-path-to-node=\"4,1,1,0,0\" data-index-in-node=\"0\"\u003ePurity\u003c\/b\u003e: Verified at 99% purity.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb data-path-to-node=\"12,2,1,6,0\" data-index-in-node=\"0\"\u003eRegulatory Note:\u003c\/b\u003e Research Use Only.\u003c\/p\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172141736159,"sku":null,"price":79.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/ChatGPT_Image_May_20_2026_11_51_43_PM.png?v=1779301325"},{"product_id":"nad","title":"NAD+","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 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th{background:var(--nv);color:#fff;font-size:11.5px;letter-spacing:1.2px;text-transform:uppercase;font-weight:700}.pp-pdp .pp-dose td:first-child{font-weight:700;color:var(--nv);white-space:nowrap}.pp-pdp .pp-step{counter-reset:s;list-style:none;padding:0;margin:0 0 18px}.pp-pdp .pp-step li{position:relative;padding:0 0 11px 34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eCellular energy, repair and ageing\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e100mg daily, 5 on\/2 off\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eapprox 10 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eNAD+ is not a peptide. It is a molecule every cell in your body uses to turn food into usable energy, and to run its DNA repair and maintenance machinery.\u003c\/p\u003e\n\u003cp\u003eLevels fall with age. People use injectable NAD+ for energy, mental clarity, recovery and general longevity protocols. It is taken each morning, five days on and two days off — not in the evening, because it can interfere with sleep.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA coenzyme central to energy production and DNA repair\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eEnergy, mental clarity, recovery, longevity protocols\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e100mg daily, 5 days on \/ 2 off, for 8–16 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eNAD+ has two jobs, and mixing them up is the most common mistake made about it.\u003c\/p\u003e\n\u003cp\u003eThe first is energy. It shuttles electrons through the reactions that convert food into ATP, and it is recycled each time rather than used up.\u003c\/p\u003e\n\u003cp\u003eThe second is maintenance. A group of repair and signalling enzymes — including the sirtuins and the DNA-damage repair enzymes — physically consume NAD+ every time they act. That is where supply becomes the limit, and why levels falling with age matters.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-nad.png?v=1785967535\" alt=\"NAD+ molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eNAD+ occupies two distinct roles in cell biology, and conflating them is the commonest error in describing it.\u003c\/p\u003e\n\u003cp\u003eThe first is catalytic. As the NAD+\/NADH couple it is the principal hydride acceptor of intermediary metabolism, cycling through several hundred dehydrogenase reactions: GAPDH in glycolysis, the isocitrate, α-ketoglutarate and malate dehydrogenases of the TCA cycle, and the dehydrogenase steps of β-oxidation. NADH then delivers electrons to complex I. In this role NAD+ is regenerated, not consumed, and the ratio of oxidised to reduced forms — rather than absolute quantity — sets the direction of flux. Phosphorylation by NAD kinase yields NADP+, whose reduced form NADPH drives reductive biosynthesis and regenerates glutathione and thioredoxin.\u003c\/p\u003e\n\u003cp\u003eThe second role is as a consumed substrate. Sirtuins (SIRT1–7) are NAD+-dependent deacylases: each turnover cleaves NAD+, releasing nicotinamide and 2'-O-acyl-ADP-ribose. PARP1 and PARP2 consume it heavily during poly-ADP-ribosylation in the DNA damage response. The ecto-enzymes CD38 and CD157 hydrolyse it to cyclic ADP-ribose, and SARM1 consumes it during axonal degeneration. Because these enzymes destroy the molecule, their activity is constrained by NAD+ availability — the basis for research linking NAD+ concentration to sirtuin signalling.\u003c\/p\u003e\n\u003cp\u003eSupply comes mainly from the salvage pathway, where NAMPT converts nicotinamide to NMN and the compartment-specific NMNAT isoforms adenylylate it to NAD+ in nucleus, cytosol and mitochondria. De novo synthesis from tryptophan via the kynurenine pathway and the Preiss-Handler route from nicotinic acid contribute less. Tissue NAD+ declines with age, with increased CD38 expression among the implicated mechanisms (Camacho-Pereira et al., Cell Metabolism, 2016).\u003c\/p\u003e\n\u003cp\u003eWhat distinguishes NAD+ from its precursors is transport. It is a large, doubly charged dinucleotide with poor membrane permeability, and extracellular NAD+ is substantially degraded by CD38 and CD73 to NMN and NR before uptake. Whether raising intracellular NAD+ is better served by the dinucleotide itself or by precursors remains an open question in the literature (Rajman, Chwalek and Sinclair, Cell Metabolism, 2018).\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eTwo roles: fuel and maintenance\u003c\/h3\u003e\n\u003cp\u003eIt is recycled endlessly in energy production, but permanently consumed by repair and signalling enzymes.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eRepair enzymes eat it\u003c\/h3\u003e\n\u003cp\u003eSirtuins and DNA-repair enzymes destroy NAD+ each time they work, so their activity is limited by how much is available.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eTissue levels decline with age\u003c\/h3\u003e\n\u003cp\u003ePublished work links the decline partly to an enzyme that becomes more active as we get older.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eInjection bypasses a real problem\u003c\/h3\u003e\n\u003cp\u003eNAD+ crosses cell membranes poorly and is broken down before it gets in, which is why route of delivery matters.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eNAD+ 1000mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 50mg of NAD+.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e50mg daily\u003c\/td\u003e\n\u003ctd\u003e10 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e100mg daily\u003c\/td\u003e\n\u003ctd\u003e20 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: approx 10 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Morning only. Do not inject in the evening — NAD+ activates sirtuin pathways that can interfere with sleep. 5 days on, 2 days off.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 8 to 16 weeks.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eIs NAD+ a peptide?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo. It is a dinucleotide — nicotinamide mononucleotide joined to adenosine monophosphate through a pyrophosphate bridge. It is stocked alongside research peptides because it is handled and reconstituted in the same way, not because it belongs to the same chemical class.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does NAD+ differ from NMN and NR?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNMN and NR are biosynthetic precursors that enter the salvage pathway upstream of NAD+. Both are smaller and more readily transported. NAD+ itself is doubly charged and poorly membrane-permeant, and extracellular NAD+ is largely degraded to NMN and NR by CD38 and CD73 before it reaches the cell interior.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is it studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eResearch contexts include mitochondrial function, sirtuin-dependent signalling, DNA repair capacity via PARP activity, and age-associated decline in tissue NAD+ concentration. Rajman, Chwalek and Sinclair (Cell Metabolism, 2018) review the in vivo evidence for NAD-boosting strategies.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is it less stable than the peptides you supply?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eThe nicotinamide-ribose glycosidic bond hydrolyses under alkaline conditions and degrades with heat and light. Lyophilised NAD+ is also strongly hygroscopic. Both properties argue for preparing solutions close to the point of use and keeping the dry powder sealed and desiccated.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our \u003ca href=\"\/pages\/quality-standards\"\u003equality standards page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our \u003ca href=\"\/pages\/delivery-process\"\u003edelivery process page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eCan I return an order?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnder the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out in our \u003ca href=\"\/pages\/return-refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/anti-aging-longevity-peptides\"\u003eAlso in Anti-Ageing \u0026amp; Longevity\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/mots-c\"\u003eMOTS-C\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/glutathione\"\u003eGlutathione\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/cellular-longevity-peptide-stack\"\u003eCellular Longevity Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eMetabolic Reset Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"Is NAD+ a peptide?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No. It is a dinucleotide — nicotinamide mononucleotide joined to adenosine monophosphate through a pyrophosphate bridge. It is stocked alongside research peptides because it is handled and reconstituted in the same way, not because it belongs to the same chemical class.\"}},{\"@type\":\"Question\",\"name\":\"How does NAD+ differ from NMN and NR?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"NMN and NR are biosynthetic precursors that enter the salvage pathway upstream of NAD+. Both are smaller and more readily transported. NAD+ itself is doubly charged and poorly membrane-permeant, and extracellular NAD+ is largely degraded to NMN and NR by CD38 and CD73 before it reaches the cell interior.\"}},{\"@type\":\"Question\",\"name\":\"What is it studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Research contexts include mitochondrial function, sirtuin-dependent signalling, DNA repair capacity via PARP activity, and age-associated decline in tissue NAD+ concentration. Rajman, Chwalek and Sinclair (Cell Metabolism, 2018) review the in vivo evidence for NAD-boosting strategies.\"}},{\"@type\":\"Question\",\"name\":\"Why is it less stable than the peptides you supply?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"The nicotinamide-ribose glycosidic bond hydrolyses under alkaline conditions and degrades with heat and light. Lyophilised NAD+ is also strongly hygroscopic. Both properties argue for preparing solutions close to the point of use and keeping the dry powder sealed and desiccated.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our quality standards page at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our delivery process page at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"Can I return an order?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Under the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172143669471,"sku":null,"price":79.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/NAD_1.png?v=1778674618"},{"product_id":"tesamorelin","title":"Tesamorelin 20mg","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 auto;padding:0 24px}.pp-pdp 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li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eVisceral (deep abdominal) fat reduction\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e2mg daily\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e10 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eTesamorelin is a stabilised version of the brain signal that tells the pituitary to release growth hormone. It is the only compound in this category with regulatory approval anywhere — approved in the US for a specific HIV-related condition.\u003c\/p\u003e\n\u003cp\u003eIt is used for visceral fat: the deep abdominal fat that sits around the organs, as distinct from the fat you can pinch. That distinction is the whole reason people choose it.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA stabilised analogue of growth hormone-releasing hormone\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eReducing visceral (deep abdominal) fat\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e2mg once daily in the evening, 8–12 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eIt works on your pituitary, prompting it to release more of your own growth hormone — rather than injecting growth hormone directly.\u003c\/p\u003e\n\u003cp\u003eThat matters. Because the release is still your body's own pulsing system, your natural feedback brakes stay in place instead of being overridden.\u003c\/p\u003e\n\u003cp\u003eThe growth hormone then raises fat-breakdown activity. Visceral fat carries more growth hormone receptors than fat under the skin and responds more strongly, which is why the effect shows up there first.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-tesamorelin.png?v=1785967669\" alt=\"Tesamorelin molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eTesamorelin is a stabilised analogue of human growth hormone-releasing hormone. The native molecule, GHRH(1-44), is rapidly inactivated in circulation by dipeptidyl peptidase-4, which cleaves the N-terminal dipeptide and abolishes receptor activity. Tesamorelin carries a trans-3-hexenoyl group attached to the N-terminal tyrosine, which sterically obstructs that cleavage and materially extends the functional half-life while preserving affinity for the receptor.\u003c\/p\u003e\n\u003cp\u003eThe target is the GHRH receptor, a class B G-protein-coupled receptor expressed on pituitary somatotrophs. Agonism raises intracellular cAMP, activates protein kinase A, and increases both the synthesis and the pulsatile release of endogenous growth hormone. This is the mechanistically important distinction from exogenous recombinant growth hormone: tesamorelin amplifies the animal's own secretory pulses rather than imposing a continuous exogenous concentration, so the pituitary's negative feedback loops — somatostatin tone and IGF-1 feedback — remain intact and continue to constrain the response.\u003c\/p\u003e\n\u003cp\u003eDownstream, elevated growth hormone acts on hepatic and peripheral GH receptors, raising IGF-1 and increasing hormone-sensitive lipase activity in adipose tissue. Visceral adipose tissue is comparatively rich in GH receptors and lipolytically responsive, which is the mechanistic basis for the tissue-selective findings reported in the clinical literature.\u003c\/p\u003e\n\u003cp\u003eThat literature is unusually solid for this compound class. Falutz et al. (New England Journal of Medicine, 2007) reported reductions in visceral adipose tissue in a randomised placebo-controlled trial in patients with HIV-associated excess abdominal fat, findings extended in a pooled analysis of two phase 3 trials. Stanley et al. (Lancet HIV, 2019) subsequently reported effects on hepatic fat in a randomised, double-blind, multicentre trial of non-alcoholic fatty liver disease in HIV.\u003c\/p\u003e\n\u003cp\u003eTesamorelin differs from growth hormone secretagogues such as ipamorelin, which act at the ghrelin receptor (GHS-R1a) rather than the GHRH receptor. The two pathways are distinct and, in research models, additive; CJC-1295 is the closer comparator, being a GHRH analogue of different design.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eTargets deep abdominal fat\u003c\/h3\u003e\n\u003cp\u003eVisceral fat is richer in growth hormone receptors and more responsive, which is why results concentrate there.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eUses your own hormone release\u003c\/h3\u003e\n\u003cp\u003eIt amplifies the pituitary's natural pulses rather than replacing them with a flat exogenous dose.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eBacked by a NEJM trial\u003c\/h3\u003e\n\u003cp\u003eVisceral fat reduction was reported in a New England Journal of Medicine randomised trial.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eAlso studied for liver fat\u003c\/h3\u003e\n\u003cp\u003eA randomised trial published in Lancet HIV examined its effect on fat in the liver.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eTesamorelin 20mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 1mg of Tesamorelin.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e1mg daily\u003c\/td\u003e\n\u003ctd\u003e10 units (0.1ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e2mg daily\u003c\/td\u003e\n\u003ctd\u003e20 units (0.2ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 10 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Evening preferred, at least 2 hours after your last meal. This aligns with the body's natural growth hormone release during sleep.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 8 to 12 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does tesamorelin differ from exogenous growth hormone?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eRecombinant growth hormone supplies the hormone directly, overriding pituitary regulation. Tesamorelin acts one step upstream at the GHRH receptor, amplifying the pituitary's own pulsatile secretion. Somatostatin tone and IGF-1 negative feedback remain intact, so the physiological pattern of release is preserved in research models.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does it differ from ipamorelin or CJC-1295?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIpamorelin is a ghrelin receptor (GHS-R1a) agonist — a different receptor and a different pathway. CJC-1295 is the closer comparator, being a GHRH analogue, though of different structural design. Tesamorelin is the GHRH analogue with the most substantial randomised controlled trial literature behind it.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat has tesamorelin been studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIts principal published trials examined visceral adipose tissue in HIV-associated lipodystrophy (Falutz et al., NEJM, 2007, and a pooled phase 3 analysis) and hepatic fat in non-alcoholic fatty liver disease in HIV (Stanley et al., Lancet HIV, 2019). Purist supplies the compound for laboratory research only.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is visceral fat a distinct research target?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eVisceral adipose tissue differs from subcutaneous fat in receptor density, lipolytic responsiveness and metabolic activity. It is comparatively rich in growth hormone receptors, which is the mechanistic basis for the tissue-selective effects reported in the tesamorelin trials.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \u003ca href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \u003ca href=\"\/pages\/delivery-process\"\u003eDelivery Process\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eCan I return an order?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnder the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out in our \u003ca href=\"\/pages\/return-refund-policy\"\u003eRefund Policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/fat-loss-peptides\"\u003eAlso in Fat Loss \u0026amp; Metabolic Research\u003c\/a\u003eRetatrutide\u003ca class=\"pp-chip\" href=\"\/products\/cjc-1295-w-dac\"\u003eCJC-1295 w DAC\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eVisceral Fat Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/gh-optimisation-peptide-stack\"\u003eGH Optimisation Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eMetabolic Reset Peptide Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"How does tesamorelin differ from exogenous growth hormone?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Recombinant growth hormone supplies the hormone directly, overriding pituitary regulation. Tesamorelin acts one step upstream at the GHRH receptor, amplifying the pituitary's own pulsatile secretion. Somatostatin tone and IGF-1 negative feedback remain intact, so the physiological pattern of release is preserved in research models.\"}},{\"@type\":\"Question\",\"name\":\"How does it differ from ipamorelin or CJC-1295?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Ipamorelin is a ghrelin receptor (GHS-R1a) agonist, a different receptor and a different pathway. CJC-1295 is the closer comparator, being a GHRH analogue, though of different structural design. Tesamorelin is the GHRH analogue with the most substantial randomised controlled trial literature behind it.\"}},{\"@type\":\"Question\",\"name\":\"What has tesamorelin been studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Its principal published trials examined visceral adipose tissue in HIV-associated lipodystrophy (Falutz et al., NEJM, 2007, and a pooled phase 3 analysis) and hepatic fat in non-alcoholic fatty liver disease in HIV (Stanley et al., Lancet HIV, 2019). Purist supplies the compound for laboratory research only.\"}},{\"@type\":\"Question\",\"name\":\"Why is visceral fat a distinct research target?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Visceral adipose tissue differs from subcutaneous fat in receptor density, lipolytic responsiveness and metabolic activity. It is comparatively rich in growth hormone receptors, which is the mechanistic basis for the tissue-selective effects reported in the tesamorelin trials.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"Can I return an order?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Under the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172150354143,"sku":null,"price":59.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/TESAMORELIN.png?v=1778674630"}],"url":"https:\/\/puristpeptides.nl\/collections\/anti-aging-longevity-peptides.oembed","provider":"Purist Peptides NL","version":"1.0","type":"link"}