{"title":"Best Seller","description":"","products":[{"product_id":"bpc-157","title":"BPC-157 10mg","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 auto;padding:0 24px}.pp-pdp .pp-kick{color:var(--tl);font-size:12px;letter-spacing:2.16px;text-transform:uppercase;font-weight:600;margin:0 0 12px}.pp-pdp .pp-sec{padding:56px 0}.pp-pdp .pp-alt{background:var(--sf)}.pp-pdp .pp-sec h2{font-size:30px}.pp-pdp .pp-prose p{font-size:15.5px;color:var(--mut)}.pp-pdp .pp-prose p 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.pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eSoft-tissue recovery and repair\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e500mcg daily\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e20 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eBPC-157 is a small peptide — fifteen amino acids long — originally identified in human gastric juice. It is one of the most widely studied compounds in the recovery category.\u003c\/p\u003e\n\u003cp\u003ePeople use it for slow-healing soft-tissue problems: tendon and ligament strains, muscle tears, joint niggles that keep coming back, and gut irritation. The interest comes from animal studies where it improved blood supply to damaged tissue and sped up repair.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA 15-amino-acid peptide, injected subcutaneously\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eTendon, ligament, muscle and gut recovery\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e500mcg once daily for 4–8 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eHealing is limited by blood supply. Damaged tendon and ligament tissue has very little of it, which is why these injuries take months rather than weeks.\u003c\/p\u003e\n\u003cp\u003eBPC-157's main reported effect is on that bottleneck. In animal studies it encourages the growth of new blood vessels into damaged tissue and helps repair cells move to where they are needed.\u003c\/p\u003e\n\u003cp\u003eAlmost all of the evidence is from animal and laboratory work. Human trials are limited. It is not a licensed medicine anywhere.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-bpc-157.png?v=1785967535\" alt=\"BPC-157 molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eBPC-157 is a 15-residue fragment corresponding to a partial sequence of Body Protection Compound, a protein isolated from human gastric juice. It carries no cysteine residues and no disulphide constraint, and is notable within the peptide literature for resisting hydrolysis in gastric acid — the property from which the \"stable gastric pentadecapeptide\" designation derives.\u003c\/p\u003e\n\u003cp\u003eNo single high-affinity receptor for BPC-157 has been identified. The mechanistic literature instead describes convergence on two systems. The first is angiogenic signalling. Hsieh et al. (Journal of Molecular Medicine, 2017) reported that BPC-157's pro-angiogenic activity is associated with activation and upregulation of VEGFR2, with downstream signalling through the Akt–eNOS axis; VEGFR2 blockade attenuated the effect. This places the compound upstream of endothelial cell migration and tube formation rather than acting as a direct growth factor mimetic.\u003c\/p\u003e\n\u003cp\u003eThe second is the nitric oxide system. Work from Sikirić's group and others reports that BPC-157 modulates NO production bidirectionally, counteracting both L-NAME-induced NO blockade and L-arginine-induced NO excess in the same models. Hsieh et al. (Scientific Reports, 2020) described modulation of vasomotor tone via a Src–caveolin-1–eNOS pathway. The practical consequence in these models is homeostatic rather than unidirectional: the peptide appears to restore perturbed NO signalling in either direction.\u003c\/p\u003e\n\u003cp\u003eIn connective tissue specifically, Chang et al. (Journal of Applied Physiology, 2011) reported increased tendon fibroblast outgrowth, survival and migration in vitro, with associated changes in focal adhesion kinase and paxillin signalling — the machinery governing cell adhesion and directed migration during repair.\u003c\/p\u003e\n\u003cp\u003eThis distinguishes BPC-157 from TB-500, the adjacent recovery-research compound. TB-500 acts intracellularly on the actin cytoskeleton through G-actin sequestration. BPC-157's described actions are predominantly extracellular and vascular. The two are frequently studied together for that reason.\u003c\/p\u003e\n\u003cp\u003eThe entire evidence base is preclinical — rodent and in vitro. Human clinical trial data are limited, and reviews such as Józwiak et al. (Pharmaceuticals, 2025) are explicit about this gap.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eImproves blood supply to damaged tissue\u003c\/h3\u003e\n\u003cp\u003eIn animal studies it triggered new blood vessel growth — the main thing that limits tendon and ligament healing.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eHelps repair cells migrate\u003c\/h3\u003e\n\u003cp\u003eLaboratory work on tendon cells showed faster growth, better survival and improved movement toward the injury site.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eWidely studied for gut irritation\u003c\/h3\u003e\n\u003cp\u003eA large share of the published work looks at protection of the stomach and intestinal lining.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eEvidence is preclinical\u003c\/h3\u003e\n\u003cp\u003eThe research is overwhelmingly animal and in-vitro. Controlled human trial data remain limited.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eBPC-157 10mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 500mcg of BPC-157.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e250mcg daily\u003c\/td\u003e\n\u003ctd\u003e5 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e500mcg daily\u003c\/td\u003e\n\u003ctd\u003e10 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 20 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once daily. For acute injury, twice daily — morning and evening.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 4 to 8 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen or inject near the area of concern\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is BPC-157 studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003ePublished preclinical work covers tendon, ligament and muscle injury models, gastrointestinal mucosal integrity, and nitric oxide signalling. Reviews including Józwiak et al. (Pharmaceuticals, 2025) survey this literature. The work is overwhelmingly rodent and in vitro; human clinical evidence is limited.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does BPC-157 differ from TB-500?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eBPC-157's described actions are largely extracellular and vascular, centring on VEGFR2 and nitric oxide signalling. TB-500 acts intracellularly, sequestering G-actin and influencing cytoskeletal remodelling and cell migration. Because the mechanisms are distinct rather than overlapping, the two are commonly examined in parallel.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eDoes BPC-157 bind a specific receptor?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo single high-affinity receptor has been identified. The mechanistic literature describes convergence on VEGFR2-associated angiogenic signalling and on modulation of the nitric oxide system, rather than a defined ligand-receptor pair. This remains an open question in the field.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is it described as \"stable gastric\"?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eThe designation reflects the peptide's reported resistance to hydrolysis in human gastric juice, a property unusual among peptides of this size and the basis of much of the early gastrointestinal research interest.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \u003ca href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \u003ca href=\"\/pages\/delivery-process\"\u003eDelivery Process\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eCan I return an order?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnder the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out in our \u003ca href=\"\/pages\/return-refund-policy\"\u003eRefund Policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/recovery-repair-peptides\"\u003eAlso in Recovery \u0026amp; Tissue Repair\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/bpc-157-tb-500\"\u003eWolverine Stack\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/recovery-peptide-stack\"\u003eRecovery Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/performance-recovery-peptide-stack\"\u003ePerformance Recovery Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin Recovery Peptide Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What is BPC-157 studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Published preclinical work covers tendon, ligament and muscle injury models, gastrointestinal mucosal integrity, and vascular and nitric oxide signalling. Reviews including Jozwiak et al. (Pharmaceuticals, 2025) survey this literature. The work is overwhelmingly rodent and in vitro; human clinical evidence is limited.\"}},{\"@type\":\"Question\",\"name\":\"How does BPC-157 differ from TB-500?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"BPC-157's described actions are largely extracellular and vascular, centring on VEGFR2 and nitric oxide signalling. TB-500 acts intracellularly, sequestering G-actin and influencing cytoskeletal remodelling and cell migration. Because the mechanisms are distinct rather than overlapping, the two are commonly examined in parallel.\"}},{\"@type\":\"Question\",\"name\":\"Does BPC-157 bind a specific receptor?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No single high-affinity receptor has been identified. The mechanistic literature describes convergence on VEGFR2-associated angiogenic signalling and on modulation of the nitric oxide system, rather than a defined ligand-receptor pair. This remains an open question in the field.\"}},{\"@type\":\"Question\",\"name\":\"Why is it described as a stable gastric pentadecapeptide?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"The designation reflects the peptide's reported resistance to hydrolysis in human gastric juice, a property unusual among peptides of this size and the basis of much of the early gastrointestinal research interest.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"Can I return an order?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Under the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172129054943,"sku":null,"price":39.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/1000744347_6737fde0-0f8e-48a2-874a-ea19f9f6fba5.png?v=1778674589"},{"product_id":"bpc-157-tb-500","title":"BPC-157 + TB-500 - Wolverine Stack","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp 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34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eInjury recovery — two compounds, one vial\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e500mcg of each, daily\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e20 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eThe Wolverine Stack is BPC-157 and TB-500 supplied together — 10mg of each in a single vial.\u003c\/p\u003e\n\u003cp\u003eIt is the most common pairing in the recovery category. People use it after a specific injury, or through a heavy training block, because the two compounds cover different parts of the repair process rather than doubling up on the same one.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eBPC-157 10mg + TB-500 10mg in one vial\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eTendon, ligament and muscle injury recovery\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e500mcg of each, once daily, for 4–8 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eRepair needs two things: blood getting to the damaged area, and repair cells physically moving into it.\u003c\/p\u003e\n\u003cp\u003eBPC-157 is associated with the first — new blood vessel growth into tissue that normally has a poor supply. TB-500 is associated with the second — the internal machinery cells use to migrate.\u003c\/p\u003e\n\u003cp\u003eThe two do not share a pathway, which is the entire logic of the pairing. No controlled study of the combination itself has been published; the evidence sits with each compound separately.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-bpc-157.png?v=1785967535\" alt=\"BPC-157 molecular structure diagram — a constituent of the BPC-157 + TB-500 stack\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eThe rationale for pairing these two compounds is mechanistic separation, not additive potency. They intervene at different points in the tissue repair sequence and, on current evidence, share no common pathway.\u003c\/p\u003e\n\u003cp\u003eBPC-157 is a 15-residue fragment of a protein isolated from human gastric juice. No single high-affinity receptor has been identified for it. Its described actions are extracellular and vascular: Hsieh et al. (Journal of Molecular Medicine, 2017) associated its pro-angiogenic activity with activation and upregulation of VEGFR2 and downstream Akt–eNOS signalling, with the effect attenuated by VEGFR2 blockade. A second body of work describes bidirectional modulation of the nitric oxide system, with Hsieh et al. (Scientific Reports, 2020) reporting effects on vasomotor tone through a Src–caveolin-1–eNOS pathway. In connective tissue, Chang et al. (Journal of Applied Physiology, 2011) reported increased tendon fibroblast outgrowth, survival and migration in vitro. The functional theme is vascular supply and the extracellular signalling environment.\u003c\/p\u003e\n\u003cp\u003eTB-500 is based on thymosin beta-4, the principal G-actin sequestering peptide in mammalian cells. It binds actin monomer in a 1:1 complex and holds it unpolymerised, creating a reservoir that permits rapid, localised F-actin polymerisation at the migrating cell's leading edge. The actin-binding activity localises to the LKKTETQ motif. Malinda et al. (Journal of Investigative Dermatology, 1999) reported accelerated dermal repair in rodent models; Bock-Marquette et al. (Nature, 2004) described a separate pathway through integrin-linked kinase activation in cardiac tissue. A further mechanism operates through liberation of the N-terminal tetrapeptide Ac-SDKP by prolyl oligopeptidase and meprin-α, which carries independent anti-fibrotic activity. The functional theme here is intracellular: cytoskeletal remodelling and cell motility.\u003c\/p\u003e\n\u003cp\u003eOne compound addresses whether cells can reach the site and whether it is perfused; the other addresses the machinery cells use to move. That non-overlap is the entire basis of the pairing.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eTwo mechanisms, no overlap\u003c\/h3\u003e\n\u003cp\u003eOne targets blood supply to the injury, the other targets how repair cells move into it.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eBoth evidence bases are animal-stage\u003c\/h3\u003e\n\u003cp\u003eEach compound has substantial preclinical work behind it and limited human trial data.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eNo study of the combination\u003c\/h3\u003e\n\u003cp\u003eThe pairing is reasoned from the separate mechanisms, not from a trial of the two together.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eConvenient single vial\u003c\/h3\u003e\n\u003cp\u003eOne reconstitution, one injection, both compounds at the standard dose.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eWolverine Stack — BPC-157 10mg + TB-500 10mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 500mcg BPC-157 + 500mcg TB-500.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e250mcg each daily\u003c\/td\u003e\n\u003ctd\u003e5 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e500mcg each daily\u003c\/td\u003e\n\u003ctd\u003e10 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 20 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once daily. For acute injury, twice daily — morning and evening.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 4 to 8 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen or inject near the area of concern\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eIs there research on the combination itself?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo controlled study of BPC-157 and TB-500 administered together has been published. The evidence base consists of separate preclinical work on each compound. The pairing is a research convention grounded in mechanistic non-overlap, not a validated protocol, and should be described as such.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy are these two compounds paired?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eTheir mechanisms do not intersect. BPC-157's described actions are extracellular and vascular — VEGFR2-associated angiogenic signalling and modulation of nitric oxide. TB-500 acts intracellularly on the actin cytoskeleton, controlling the machinery of cell migration. Pairing them addresses two different constraints on tissue repair.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eDo I need to mix the two compounds separately?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo. The Wolverine Stack is supplied as a single pre-mixed vial containing 10mg of each compound, so one reconstitution covers both. Add the bacteriostatic water to the vial as supplied and follow the mixing steps above.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is it called the Wolverine Stack?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIt is a colloquial name that circulated in research and forum communities, referring to the fictional character's rapid tissue repair. It carries no scientific meaning and implies nothing about the strength of the underlying evidence, which is preclinical.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by independent HPLC at Bioindustrial Services in Boksburg, and the assay covers both compounds in the vial. We do not rely on the manufacturer's own certificate alone. The assay reports for the batches you receive are available on request, and our full testing protocol is set out at \u003ca href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \u003ca href=\"\/pages\/delivery-process\"\u003eDelivery Process\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eCan I return an order?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnder the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out in our \u003ca href=\"\/pages\/return-refund-policy\"\u003eRefund Policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/recovery-repair-peptides\"\u003eAlso in Recovery \u0026amp; Tissue Repair\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/recovery-peptide-stack\"\u003eRecovery Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/performance-recovery-peptide-stack\"\u003ePerformance Recovery Peptide Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"Is there research on the combination itself?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No controlled study of BPC-157 and TB-500 administered together has been published. The evidence base consists of separate preclinical work on each compound. The pairing is a research convention grounded in mechanistic non-overlap, not a validated protocol, and should be described as such.\"}},{\"@type\":\"Question\",\"name\":\"Why are these two compounds paired?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Their mechanisms do not intersect. BPC-157's described actions are extracellular and vascular, involving VEGFR2-associated angiogenic signalling and modulation of nitric oxide. TB-500 acts intracellularly on the actin cytoskeleton, controlling the machinery of cell migration. Pairing them addresses two different constraints on tissue repair.\"}},{\"@type\":\"Question\",\"name\":\"Do I need to mix the two compounds separately?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No. The Wolverine Stack is supplied as a single pre-mixed vial containing 10mg of each compound, so one reconstitution covers both. Add the bacteriostatic water to the vial as supplied and follow the mixing steps above.\"}},{\"@type\":\"Question\",\"name\":\"Why is it called the Wolverine Stack?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"It is a colloquial name that circulated in research and forum communities, referring to the fictional character's rapid tissue repair. It carries no scientific meaning and implies nothing about the strength of the underlying evidence, which is preclinical.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by independent HPLC at Bioindustrial Services in Boksburg, and the assay covers both compounds in the vial. We do not rely on the manufacturer's own certificate alone. The assay reports for the batches you receive are available on request, and our full testing protocol is set out at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"Can I return an order?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Under the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172130005215,"sku":null,"price":79.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/BPC-157___TB-500_1.png?v=1778674591"},{"product_id":"cjc-1295-w-dac","title":"CJC‑1295 w\/o DAC 5 mg + IPA 5 mg","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 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34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eGrowth hormone support — one injection a week\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e1mg once weekly\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e5 weeks per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eCJC-1295 with DAC is a modified version of the signal your brain uses to tell the pituitary to release growth hormone.\u003c\/p\u003e\n\u003cp\u003eIts defining feature is duration. Once injected, it clips onto a protein in your blood and stays active for days rather than minutes. That is why it is a once-weekly injection while most peptides in this category are daily.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA long-acting analogue of growth hormone-releasing hormone\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eRaising the body's own growth hormone and IGF-1 output\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e1mg once weekly, same day each week, 8–16 weeks then a 4-week break\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eYour pituitary already releases growth hormone in pulses. CJC-1295 pushes on that existing system rather than replacing it — so your body's own feedback controls still apply.\u003c\/p\u003e\n\u003cp\u003eNatural GHRH is destroyed in the bloodstream within minutes. Four small changes to the molecule block the enzymes that break it down.\u003c\/p\u003e\n\u003cp\u003eThe DAC part is the clever bit: it forms a permanent bond with albumin, the most abundant protein in blood. That makes the whole package too big for the kidneys to filter out, stretching its life from minutes to days.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-cjc-1295-w-dac.png?v=1785967669\" alt=\"CJC-1295 with DAC molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eCJC-1295 with DAC is built on GRF(1-29), the N-terminal fragment of human growth hormone-releasing hormone that retains the full receptor activity of the 44-residue native peptide. Four positions are substituted — D-Ala at 2, Gln at 8, Ala at 15 and Leu at 27 — each closing a route of degradation. The D-Ala2 substitution matters most: native GHRH is cleaved between residues 2 and 3 by dipeptidyl peptidase-IV within minutes of entering plasma, and the D-amino acid renders that bond unrecognisable. The other substitutions reduce trypsin cleavage and asparagine deamidation.\u003c\/p\u003e\n\u003cp\u003eThe Drug Affinity Complex is the more distinctive modification. A lysine is appended at position 30 and its side chain carries a maleimidopropionyl group. Maleimide reacts selectively with free thiols, and the only abundant free thiol in plasma is Cys34 of serum albumin. The peptide therefore forms a covalent thioether bond with albumin in situ, producing a conjugate too large for glomerular filtration and largely shielded from peptidase access. Circulating half-life is measured in days rather than minutes.\u003c\/p\u003e\n\u003cp\u003eReceptor engagement is conventional. The peptide binds GHRHR, a class B G protein-coupled receptor on anterior pituitary somatotrophs, coupling through Gs to adenylyl cyclase. The cAMP rise activates protein kinase A, which phosphorylates CREB and drives Pit-1-dependent GH gene transcription alongside calcium-mediated release of stored granules. Hepatic GH receptor signalling then raises IGF-1.\u003c\/p\u003e\n\u003cp\u003eTwo contrasts define its position. Against CJC-1295 without DAC, which shares the substitutions but lacks the linker, the difference is purely pharmacokinetic — a discrete pulse against a sustained elevation of baseline. Against ghrelin mimetics such as Ipamorelin, acting at GHS-R1a, the receptor and pathway differ entirely. Teichman et al. (J Clin Endocrinol Metab, 2006) reported sustained GH and IGF-1 elevation after single subcutaneous doses in healthy adults; Ionescu and Frohman (J Clin Endocrinol Metab, 2006) found endogenous pulsatility persisted despite continuous receptor stimulation.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eOne injection covers a week\u003c\/h3\u003e\n\u003cp\u003eBonding to blood albumin extends its half-life to roughly 6–8 days.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eUses your own GH pulses\u003c\/h3\u003e\n\u003cp\u003eIt amplifies the pituitary's natural pulsatile release rather than imposing a flat, constant level.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eSustained IGF-1 rise in humans\u003c\/h3\u003e\n\u003cp\u003eA published clinical study reported sustained growth hormone and IGF-1 elevation after single doses.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003ePulsing is preserved\u003c\/h3\u003e\n\u003cp\u003eHuman work found the natural pulse pattern persisted rather than flattening out under continuous stimulation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eCJC-1295 w DAC 5mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 250mcg of CJC-1295 w DAC.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e500mcg once weekly\u003c\/td\u003e\n\u003ctd\u003e20 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e1mg once weekly\u003c\/td\u003e\n\u003ctd\u003e40 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 5 weeks\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"pp-warn\"\u003e\u003cp\u003eCJC-1295 w DAC has a half-life of 6 to 8 days. Inject once on the same day each week. Do not inject daily.\u003c\/p\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once weekly on the same day each week. Inject on an empty stomach where possible.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 8 to 16 weeks, then take a 4-week break.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the DAC in CJC-1295 with DAC?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eDAC stands for Drug Affinity Complex — a maleimidopropionyl group on a C-terminal lysine that reacts with the free thiol of Cys34 on serum albumin. The resulting covalent conjugate is too large for renal filtration, which is why the compound persists for days rather than minutes.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does it differ from CJC-1295 without DAC?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eBoth share the same four amino acid substitutions on the GRF(1-29) backbone. Only the DAC version carries the albumin-binding linker. Without it, the peptide is cleared rapidly and produces a discrete pulse of GH release; with it, receptor stimulation is continuous and baseline GH and IGF-1 are elevated across days.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does it differ from Ipamorelin?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eDifferent receptor entirely. CJC-1295 acts at the GHRH receptor on pituitary somatotrophs. Ipamorelin is a ghrelin mimetic acting at GHS-R1a, which stimulates GH release through a separate pathway and reduces somatostatin tone. The two are studied together in research models precisely because the mechanisms are independent.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat has it been studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003ePublished human pharmacology is limited to the 2006 JCEM papers, which examined GH and IGF-1 secretion kinetics in healthy adults. Later research interest has centred on the somatotropic axis, body composition and sleep architecture in preclinical settings.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our \u003ca href=\"\/pages\/quality-standards\"\u003equality standards page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our \u003ca href=\"\/pages\/delivery-process\"\u003edelivery process page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the returns policy?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials in original condition may be returned within the stated window; full terms are in our \u003ca href=\"\/pages\/return-refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/lean-muscle-growth-peptides\"\u003eAlso in Lean Muscle \u0026amp; Growth Hormone\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/tesamorelin\"\u003eTesamorelin\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/mots-c\"\u003eMOTS-C\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/gh-optimisation-peptide-stack\"\u003eGH Optimisation Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/lean-growth-peptide-stack\"\u003eLean Growth Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/performance-recovery-peptide-stack\"\u003ePerformance Recovery Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/deep-sleep-peptide-stack\"\u003eDeep Sleep Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What is the DAC in CJC-1295 with DAC?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"DAC stands for Drug Affinity Complex — a maleimidopropionyl group on a C-terminal lysine that reacts with the free thiol of Cys34 on serum albumin. The resulting covalent conjugate is too large for renal filtration, which is why the compound persists for days rather than minutes.\"}},{\"@type\":\"Question\",\"name\":\"How does it differ from CJC-1295 without DAC?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Both share the same four amino acid substitutions on the GRF(1-29) backbone. Only the DAC version carries the albumin-binding linker. Without it, the peptide is cleared rapidly and produces a discrete pulse of GH release; with it, receptor stimulation is continuous and baseline GH and IGF-1 are elevated across days.\"}},{\"@type\":\"Question\",\"name\":\"How does it differ from Ipamorelin?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Different receptor entirely. CJC-1295 acts at the GHRH receptor on pituitary somatotrophs. Ipamorelin is a ghrelin mimetic acting at GHS-R1a, which stimulates GH release through a separate pathway and reduces somatostatin tone. The two are studied together in research models precisely because the mechanisms are independent.\"}},{\"@type\":\"Question\",\"name\":\"What has it been studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Published human pharmacology is limited to the 2006 JCEM papers, which examined GH and IGF-1 secretion kinetics in healthy adults. Subsequent research interest has centred on the somatotropic axis, body composition and sleep architecture in preclinical and observational settings.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our quality standards page at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our delivery process page at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"What is the returns policy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Unopened vials in original condition may be returned within the stated window; full terms are in our refund policy at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172130627807,"sku":null,"price":59.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/CJC_1295w_oDAC5mg_IPA5mg.png?v=1779265514"},{"product_id":"dsip","title":"DSIP","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp 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.pp-step{counter-reset:s;list-style:none;padding:0;margin:0 0 18px}.pp-pdp .pp-step li{position:relative;padding:0 0 11px 34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eSleep quality and sleep onset\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e200mcg daily\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e50 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eDSIP — Delta Sleep-Inducing Peptide — was discovered in the 1970s by collecting fluid from the brains of rabbits in deep sleep and finding it induced the same deep sleep in other animals.\u003c\/p\u003e\n\u003cp\u003eIt is used for sleep quality, particularly deep sleep, and for people whose sleep is disrupted by stress. It is taken 30 to 60 minutes before bed.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA nine-amino-acid peptide first isolated from the brain during deep sleep\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eDeep sleep, sleep onset, stress-disrupted sleep\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e200mcg 30–60 minutes before bed, 8–12 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eHonestly: nobody knows. That is the standing position in the published literature, not a hedge.\u003c\/p\u003e\n\u003cp\u003eNo receptor for DSIP has ever been identified, so there is no confirmed mechanism. Proposed contributions include effects on the brain's calming and stimulating signals and on stress hormone output.\u003c\/p\u003e\n\u003cp\u003eIt also clears from the blood very quickly, yet effects have been reported long after it is gone — which is exactly why researchers have called it an unresolved riddle.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-dsip.png?v=1785967535\" alt=\"DSIP molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eDSIP originates in one of the more unusual isolation experiments in neuropeptide research. Working in Basel in the 1970s, Monnier and Schoenenberger perfused the cerebral ventricular system of rabbits during electrically induced delta-wave sleep and recovered a dialysate fraction that induced delta EEG activity when transferred to recipient animals. The active material was characterised as a nonapeptide and synthesised; Schoenenberger et al. (Pflügers Archiv, 1977) reported the amino acid analysis, sequence and activity of the synthetic compound.\u003c\/p\u003e\n\u003cp\u003eThe molecule is small, uncharged at several positions and carries no disulphide bridge. It is reported to cross the blood-brain barrier, and its plasma half-life is short — a combination that has complicated interpretation of the experimental literature, since measurable central effects have been reported at time points well beyond the peptide's detectable presence in circulation.\u003c\/p\u003e\n\u003cp\u003eNo specific DSIP receptor has been cloned or characterised. This is the central unresolved problem in the field, and it is the reason Kovalzon and Strekalova titled their mini-review in the Journal of Neurochemistry (2006) \"Delta sleep-inducing peptide (DSIP): a still unresolved riddle\". Without an identified binding site, the mechanistic literature is necessarily descriptive. Proposed contributions include modulation of GABAergic and glutamatergic tone, interaction with opioid systems, and influence on hypothalamic–pituitary–adrenal axis output.\u003c\/p\u003e\n\u003cp\u003eThe functional literature is correspondingly mixed. Reported observations extend well beyond sleep — into thermoregulation, stress adaptation, and oxidative stress models — and several groups have failed to reproduce the original delta-wave findings. Bes et al. (Neuropsychobiology, 1992) conducted a double-blind study in chronic insomniacs and reported statistically significant but weak effects on sleep efficiency and latency, with no improvement in subjective sleep quality; the authors concluded short-term administration was unlikely to be of major therapeutic benefit.\u003c\/p\u003e\n\u003cp\u003eMechanistically, DSIP is therefore unlike the GABA-A positive allosteric modulators that dominate hypnotic pharmacology. It is not a sedative in that sense, and the research interest lies in the endogenous regulatory system it may represent rather than in a defined receptor action.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eDiscovered by transferring deep sleep\u003c\/h3\u003e\n\u003cp\u003eFluid taken from rabbits in delta-wave sleep induced the same brain-wave pattern in recipient animals.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eSequence confirmed in 1977\u003c\/h3\u003e\n\u003cp\u003eThe synthetic version was characterised and published as a nine-amino-acid peptide.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eNo receptor has ever been found\u003c\/h3\u003e\n\u003cp\u003eFifty years on, the binding site and mechanism remain unidentified.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eHuman trial results were weak\u003c\/h3\u003e\n\u003cp\u003eA double-blind insomnia study reported only weak effects — worth knowing before you buy.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eDSIP 10mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 500mcg of DSIP.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e100mcg daily\u003c\/td\u003e\n\u003ctd\u003e2 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e200mcg daily\u003c\/td\u003e\n\u003ctd\u003e4 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 50 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e 30 to 60 minutes before bedtime.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 8 to 12 weeks, then take a break.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is DSIP studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003ePublished work covers sleep architecture and delta EEG activity, thermoregulation, stress adaptation and hypothalamic–pituitary–adrenal signalling, and oxidative stress models. The literature is small, spread across four decades, and inconsistent in its findings. Purist supplies the compound for laboratory research only.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eDoes DSIP bind a known receptor?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo. No DSIP receptor has been cloned or characterised, and this remains the principal open question in the field — the basis for Kovalzon and Strekalova's 2006 Journal of Neurochemistry review describing the peptide as a still unresolved riddle.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is the DSIP sleep literature inconsistent?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eSeveral groups have been unable to reproduce the original delta-wave findings, and reported central effects often outlast the peptide's measurable presence in circulation. Study designs, routes and assay methods also vary considerably across the four decades of published work.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does DSIP differ from GABAergic hypnotics?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eBenzodiazepines and Z-drugs are positive allosteric modulators at the GABA-A receptor, a defined and well-characterised target. DSIP has no identified receptor and is not a sedative in that pharmacological sense; research interest centres on the endogenous system it may represent.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \u003ca href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \u003ca href=\"\/pages\/delivery-process\"\u003eDelivery Process\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the returns policy?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials in original condition may be returned under the conditions set out at \u003ca href=\"\/pages\/return-refund-policy\"\u003eRefund Policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/sleep-mood-peptides\"\u003eAlso in Sleep, Stress \u0026amp; Circadian\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/cjc-1295-w-dac\"\u003eCJC-1295 w DAC\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/nad\"\u003eNAD+\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/deep-sleep-peptide-stack\"\u003eDeep Sleep Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/recovery-peptide-stack\"\u003eRecovery Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/cellular-longevity-peptide-stack\"\u003eCellular Longevity Peptide Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What is DSIP studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Published work covers sleep architecture and delta EEG activity, thermoregulation, stress adaptation and hypothalamic-pituitary-adrenal signalling, and oxidative stress models. The literature is small, spread across four decades, and inconsistent in its findings. Purist supplies the compound for laboratory research only.\"}},{\"@type\":\"Question\",\"name\":\"Does DSIP bind a known receptor?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No. No DSIP receptor has been cloned or characterised, and this remains the principal open question in the field, the basis for Kovalzon and Strekalova's 2006 Journal of Neurochemistry review describing the peptide as a still unresolved riddle.\"}},{\"@type\":\"Question\",\"name\":\"Why is the DSIP sleep literature inconsistent?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Several groups have been unable to reproduce the original delta-wave findings, and reported central effects often outlast the peptide's measurable presence in circulation. Study designs, routes and assay methods also vary considerably across the four decades of published work.\"}},{\"@type\":\"Question\",\"name\":\"How does DSIP differ from GABAergic hypnotics?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Benzodiazepines and Z-drugs are positive allosteric modulators at the GABA-A receptor, a defined and well-characterised target. DSIP has no identified receptor and is not a sedative in that pharmacological sense; research interest centres on the endogenous system it may represent.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"What is the returns policy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Unopened vials in original condition may be returned under the conditions set out at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172131217631,"sku":null,"price":49.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/DSIP_report.png?v=1779266090"}],"url":"https:\/\/puristpeptides.nl\/collections\/best-seller.oembed","provider":"Purist Peptides NL","version":"1.0","type":"link"}