{"title":"Peptides for Skin, Collagen \u0026 Cellular Repair","description":"\u003cp\u003eResearch peptides studied for skin quality, collagen synthesis and tissue repair. Every batch independently assayed by HPLC. Research use only.\u003c\/p\u003e","products":[{"product_id":"ghk-cu","title":"GHK-CU","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 auto;padding:0 24px}.pp-pdp .pp-kick{color:var(--tl);font-size:12px;letter-spacing:2.16px;text-transform:uppercase;font-weight:600;margin:0 0 12px}.pp-pdp .pp-sec{padding:56px 0}.pp-pdp .pp-alt{background:var(--sf)}.pp-pdp .pp-sec h2{font-size:30px}.pp-pdp .pp-prose p{font-size:15.5px;color:var(--mut)}.pp-pdp .pp-prose p 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.pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eSkin firmness, tone and repair\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e2mg daily\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e50 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eGHK-Cu is a very short peptide — three amino acids — bound to copper. Your body makes it naturally, and levels drop substantially with age. That decline is what first made it interesting.\u003c\/p\u003e\n\u003cp\u003eIt is the best-known peptide for skin: firmness, tone, texture and scarring. It is also used for hair and general tissue repair.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA copper-bound tripeptide (Gly-His-Lys) the body produces naturally\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eSkin firmness and tone, scarring, hair, tissue repair\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e2mg once daily, morning, for 8–12 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eCopper is not optional for skin structure. The enzyme that cross-links collagen and elastin into mature, springy fibres cannot work without it.\u003c\/p\u003e\n\u003cp\u003eGHK-Cu's job is delivery. It picks copper up from blood proteins and hands it over to the cells and enzymes that need it — it does not lock it away.\u003c\/p\u003e\n\u003cp\u003eThat is the difference between GHK-Cu and either a copper supplement or a copper-free peptide. It also influences a wide set of genes involved in matrix turnover and antioxidant defence.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-ghk-cu.png?v=1785967535\" alt=\"GHK-Cu molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eGHK is a tripeptide — glycine, histidine, lysine — isolated from human plasma by Pickart and colleagues in the early 1970s and later identified as a fragment released during proteolysis of collagen and other matrix proteins. Its plasma concentration falls substantially with age, the observation that first prompted interest in it as an endogenous repair signal.\u003c\/p\u003e\n\u003cp\u003eThe chemistry that defines it is copper coordination. The N-terminal amine, the deprotonated amide nitrogen of the first peptide bond and the imidazole nitrogen of histidine form a square-planar chelation site for Cu2+ with very high affinity — comparable to the copper-binding site of serum albumin. GHK therefore does not sequester copper inertly; it exchanges it, accepting Cu2+ from albumin and delivering it to cellular transporters and cuproenzymes. That is why the complex behaves differently from either free copper salts or a copper-free peptide.\u003c\/p\u003e\n\u003cp\u003eThe delivery role connects directly to matrix biology. Lysyl oxidase, the enzyme that cross-links collagen and elastin fibrils into mature load-bearing structures, is copper-dependent; so are superoxide dismutase 1 and cytochrome c oxidase. Copper availability is therefore rate-limiting for matrix maturation rather than merely for matrix synthesis — the distinction between GHK-Cu and peptides that stimulate collagen transcription alone.\u003c\/p\u003e\n\u003cp\u003eBeyond copper transport, GHK-Cu shows broad transcriptional activity. Pickart and Margolina (Int J Mol Sci, 2018), drawing on Broad Institute Connectivity Map data, reported modulation of expression across a large fraction of human genes, with the pattern favouring tissue remodelling: increased collagen I, decorin and other small proteoglycans, alongside coordinated changes in matrix metalloproteinases and their TIMP inhibitors. That combination is characteristic of controlled turnover rather than simple accumulation. Pickart, Vasquez-Soltero and Margolina (BioMed Research International, 2015) reviewed the same pathways in skin regeneration, including antioxidant and anti-inflammatory gene modulation.\u003c\/p\u003e\n\u003cp\u003eAmong the skin-directed compounds on this site, GHK-Cu occupies the copper and matrix-maturation position. BPC-157 and TB-500, its partners in the GLOW and KLOW blends, act on angiogenesis and actin dynamics — adjacent but mechanistically separate.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eYour natural level falls with age\u003c\/h3\u003e\n\u003cp\u003eGHK is present in human plasma and declines substantially over the decades — the original reason for research interest.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eDelivers copper rather than storing it\u003c\/h3\u003e\n\u003cp\u003eIt binds copper about as tightly as your blood's main carrier protein, then releases it to cells.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eSupports collagen cross-linking\u003c\/h3\u003e\n\u003cp\u003eThe enzyme that turns new collagen and elastin into mature fibre is copper-dependent.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eBroad effect on repair genes\u003c\/h3\u003e\n\u003cp\u003ePublished gene-expression work reports it shifts a wide set of matrix and antioxidant genes toward controlled repair.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eGHK-Cu 100mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 5mg of GHK-Cu.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e1mg daily\u003c\/td\u003e\n\u003ctd\u003e2 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e2mg daily\u003c\/td\u003e\n\u003ctd\u003e4 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 50 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once daily, morning preferred.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 8 to 12 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is the copper part significant?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eBecause the peptide's principal characterised function is copper transport. GHK binds Cu2+ tightly enough to accept it from albumin but reversibly enough to pass it on to cellular transporters and copper-dependent enzymes. A copper-free GHK preparation is a different research material with a different activity profile.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is the reconstituted solution blue?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eThe colour comes from d-d electronic transitions of the coordinated copper(II) ion. It is expected, and its presence is a rough indication that the complex remains intact. Loss of colour or a marked colour shift suggests dissociation or degradation.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does GHK-Cu differ from BPC-157 and TB-500?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eDifferent mechanisms entirely. GHK-Cu delivers copper to matrix enzymes and modulates matrix gene expression. BPC-157 is studied chiefly for angiogenic and growth factor signalling; TB-500 for actin sequestration and cell migration. They appear together in the GLOW and KLOW blends because the pathways are complementary rather than overlapping.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is it studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003ePublished research centres on extracellular matrix remodelling, wound and tissue repair models, antioxidant and anti-inflammatory gene expression, and dermatological applications. Pickart's laboratory produced the majority of the foundational literature.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our \u003ca href=\"\/pages\/quality-standards\"\u003equality standards page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our \u003ca href=\"\/pages\/delivery-process\"\u003edelivery process page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eCan I return an order?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnder the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out in our \u003ca href=\"\/pages\/return-refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/skin-peptides\"\u003eAlso in Skin, Collagen \u0026amp; Cellular Renewal\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/glow\"\u003eGLOW\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/klow\"\u003eKLOW\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/glutathione\"\u003eGlutathione\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin Recovery Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin \u0026amp; Anti-Ageing Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"Why is the copper part significant?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Because the peptide's principal characterised function is copper transport. GHK binds Cu2+ tightly enough to accept it from albumin but reversibly enough to pass it on to cellular transporters and copper-dependent enzymes. A copper-free GHK preparation is a different research material with a different activity profile.\"}},{\"@type\":\"Question\",\"name\":\"Why is the reconstituted solution blue?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"The colour comes from d-d electronic transitions of the coordinated copper(II) ion. It is expected, and its presence is a rough indication that the complex remains intact. Loss of colour or a marked colour shift suggests dissociation or degradation.\"}},{\"@type\":\"Question\",\"name\":\"How does GHK-Cu differ from BPC-157 and TB-500?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Different mechanisms entirely. GHK-Cu delivers copper to matrix enzymes and modulates matrix gene expression. BPC-157 is studied chiefly for angiogenic and growth factor signalling; TB-500 for actin sequestration and cell migration. They appear together in the GLOW and KLOW blends because the pathways are complementary rather than overlapping.\"}},{\"@type\":\"Question\",\"name\":\"What is it studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Published research centres on extracellular matrix remodelling, wound and tissue repair models, antioxidant and anti-inflammatory gene expression, and dermatological applications. Pickart's laboratory produced the majority of the foundational literature.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our quality standards page at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our delivery process page at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"Can I return an order?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Under the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"Purist Peptides","offers":[{"title":"Default Title","offer_id":49172132004063,"sku":null,"price":54.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/GHK-CU_379beee5-6401-4db3-9d64-8ce24a44d9aa.png?v=1778674595"},{"product_id":"glow","title":"GLOW","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 auto;padding:0 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0;font-size:14.5px;color:var(--mut)}.pp-pdp .pp-tldr b{color:var(--nv);flex:0 0 148px}.pp-pdp .pp-card h3{font-size:15.5px;margin:0 0 8px;color:var(--nv);line-height:1.3}.pp-pdp .pp-more{margin-top:24px;max-width:900px}.pp-pdp .pp-more .pp-ab p{margin-bottom:12px}.pp-pdp .pp-dose{width:100%;border-collapse:collapse;margin:0 0 16px}.pp-pdp .pp-dose th,.pp-pdp .pp-dose td{text-align:left;padding:11px 14px;border-bottom:1px solid var(--ln);font-size:14.5px;color:var(--mut)}.pp-pdp .pp-dose th{background:var(--nv);color:#fff;font-size:11.5px;letter-spacing:1.2px;text-transform:uppercase;font-weight:700}.pp-pdp .pp-dose td:first-child{font-weight:700;color:var(--nv);white-space:nowrap}.pp-pdp .pp-step{counter-reset:s;list-style:none;padding:0;margin:0 0 18px}.pp-pdp .pp-step li{position:relative;padding:0 0 11px 34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eSkin quality and tissue repair\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e2.33mg daily\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e30 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eGLOW is three peptides in one vial: GHK-Cu 50mg, TB-500 10mg and BPC-157 10mg.\u003c\/p\u003e\n\u003cp\u003eIt is the standard blend for skin and recovery together — firmness and tone from GHK-Cu, tissue repair from the other two. People typically run it as a defined 8–12 week block rather than continuously.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eThree peptides in one vial: GHK-Cu, TB-500, BPC-157 (70mg total)\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eSkin firmness and tone, wound and tissue repair\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e2.33mg once daily for 8–12 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eGHK-Cu carries copper to the enzyme that cross-links collagen and elastin. Without that step you build collagen that never properly sets.\u003c\/p\u003e\n\u003cp\u003eTB-500 manages the internal scaffolding repair cells use to move into damaged tissue.\u003c\/p\u003e\n\u003cp\u003eBPC-157 is associated with new blood vessel growth into that tissue. Three separate jobs, no shared pathway — which is the reason for combining them.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-ghk-cu.png?v=1785967535\" alt=\"GHK-Cu molecular structure diagram — a constituent of the GLOW blend\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eGLOW places three separately characterised peptides in one vial. Their mechanisms do not intersect, and the rationale for combining them is that separation rather than any shared pathway.\u003c\/p\u003e\n\u003cp\u003eGHK-Cu is the tripeptide glycyl-L-histidyl-L-lysine complexed with copper(II). Its defining chemistry is copper coordination: the N-terminal amine, the deprotonated amide nitrogen of the first peptide bond and the histidine imidazole form a square-planar chelation site with affinity comparable to serum albumin. GHK does not sequester copper inertly — it accepts Cu2+ from albumin and passes it to cellular transporters and cuproenzymes, lysyl oxidase among them, the copper-dependent enzyme that cross-links collagen and elastin into mature fibrils. Pickart and Margolina (Int J Mol Sci, 2018) additionally reported broad transcriptional modulation favouring controlled matrix turnover.\u003c\/p\u003e\n\u003cp\u003eTB-500 is based on thymosin beta-4, the principal G-actin sequestering peptide in mammalian cells. It binds actin monomer in a 1:1 complex, holding it unpolymerised as a reservoir that permits rapid localised F-actin polymerisation at a migrating cell's leading edge; the activity localises to the LKKTETQ motif. Malinda et al. (Journal of Investigative Dermatology, 1999) reported accelerated dermal repair in rodent models. Its theme is intracellular — cytoskeletal remodelling and cell motility.\u003c\/p\u003e\n\u003cp\u003eBPC-157 is a 15-residue fragment of a protein isolated from human gastric juice, with no identified high-affinity receptor. Hsieh et al. (Journal of Molecular Medicine, 2017) associated its pro-angiogenic activity with VEGFR2 activation and downstream Akt–eNOS signalling, attenuated by VEGFR2 blockade. Its theme is extracellular and vascular.\u003c\/p\u003e\n\u003cp\u003eMatrix maturation, cell migration and perfusion are three separate constraints on tissue repair, and the blend addresses one apiece. Two caveats belong on the record. No controlled study of this three-compound combination has been published; the evidence base is preclinical work on each constituent. And co-formulating a redox-active copper complex with two copper-free peptides in one vial is not a characterised system.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eCollagen that matures, not just collagen\u003c\/h3\u003e\n\u003cp\u003eCopper delivery supports the enzyme that turns new collagen into mature, load-bearing fibre.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eRepair covered from two angles\u003c\/h3\u003e\n\u003cp\u003eCell movement and blood supply are handled by different constituents.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eFixed manufacture ratio\u003c\/h3\u003e\n\u003cp\u003eQuantities are set at manufacture; you cannot vary one constituent from a single vial.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eCombination itself is untested\u003c\/h3\u003e\n\u003cp\u003eEach of the three has its own research base; the three-way blend does not.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eGLOW Stack — BPC-157 10mg + TB-500 10mg + GHK-Cu 50mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 3ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 3ml of water added, each 0.1ml (10 units) you draw = 2.33mg of the total blend.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e1.17mg daily\u003c\/td\u003e\n\u003ctd\u003e5 units (0.05ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e2.33mg daily\u003c\/td\u003e\n\u003ctd\u003e10 units (0.1ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 30 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once daily, morning or evening, at a consistent time. Inject subcutaneously into the abdomen or near the area of concern.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 8 to 12 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen or inject near the area of concern\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is in the GLOW blend?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eThree peptides in one lyophilised vial: GHK-Cu, TB-500 and BPC-157, totalling 70mg of peptide content. The individual mg split between the three is not stated on the product page and should be confirmed against the batch documentation before it is quoted anywhere.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eIs there published research on the blend itself?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo. No controlled study of these three compounds administered together has been published. The evidence base consists of separate preclinical work on each constituent. The combination is a formulation convention grounded in mechanistic non-overlap, not a validated protocol, and should be described that way.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eDoes the copper in GHK-Cu affect the other two peptides in a shared vial?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eThis is not characterised in the published literature. Copper(II) is redox-active, and its behaviour alongside two copper-free peptides in one solution has not been studied to our knowledge. The practical implication is conservative handling: protect from light, avoid reducing agents and chelators, and observe the solution's colour.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does GLOW differ from KLOW?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eKLOW contains the same three peptides plus KPV, the C-terminal tripeptide of alpha-MSH, at a higher total peptide content. The addition is an inflammatory-signalling component rather than a fourth repair mechanism of the same type.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our \u003ca href=\"\/pages\/quality-standards\"\u003equality standards page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our \u003ca href=\"\/pages\/delivery-process\"\u003edelivery process page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the returns policy?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials in original condition may be returned within the stated window; full terms are in our \u003ca href=\"\/pages\/return-refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/skin-peptides\"\u003eAlso in Skin, Collagen \u0026amp; Cellular Renewal\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/klow\"\u003eKLOW\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/glutathione\"\u003eGlutathione\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin Recovery Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin \u0026amp; Anti-Ageing Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What is in the GLOW blend?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Three peptides in one lyophilised vial: GHK-Cu, TB-500 and BPC-157, totalling 70mg of peptide content. The individual mg split between the three is not stated on the product page and should be confirmed against the batch documentation before it is quoted.\"}},{\"@type\":\"Question\",\"name\":\"Is there published research on the blend itself?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No. No controlled study of these three compounds administered together has been published. The evidence base consists of separate preclinical work on each constituent. The combination is a formulation convention grounded in mechanistic non-overlap, not a validated protocol.\"}},{\"@type\":\"Question\",\"name\":\"Does the copper in GHK-Cu affect the other two peptides in a shared vial?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"This is not characterised in the published literature. Copper(II) is redox-active, and its behaviour alongside two copper-free peptides in one solution has not been studied to our knowledge. The practical implication is conservative handling: protect from light, avoid reducing agents and chelators, and observe the solution's colour.\"}},{\"@type\":\"Question\",\"name\":\"How does GLOW differ from KLOW?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"KLOW contains the same three peptides plus KPV, the C-terminal tripeptide of alpha-MSH, at a higher total peptide content. The addition is an inflammatory-signalling component rather than a fourth repair mechanism of the same type.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch is published on our quality standards page at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our delivery process page at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"What is the returns policy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Unopened vials in original condition may be returned within the stated window; full terms are in our refund policy at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172133347551,"sku":null,"price":119.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/GLOW.png?v=1778674598"},{"product_id":"glutathione","title":"Glutathione","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp 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.pp-step{counter-reset:s;list-style:none;padding:0;margin:0 0 18px}.pp-pdp .pp-step li{position:relative;padding:0 0 11px 34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eAntioxidant defence and skin brightness\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e600mg, 2–3x weekly\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eapprox 8 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eGlutathione is your body's main internal antioxidant — a three-amino-acid molecule your liver produces in large amounts and uses to neutralise damage and clear toxins.\u003c\/p\u003e\n\u003cp\u003eIt is used for antioxidant support, liver load, general recovery, and — the reason most people buy it — skin brightening and evenness of tone.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eThe body's principal internal antioxidant, a tripeptide\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eAntioxidant support, detoxification load, skin brightness and tone\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e600mg per session, 2–3 times per week, 4–8 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eGlutathione neutralises damaging molecules by sacrificing part of itself, then gets recycled back to its active form. That cycle is running constantly in every cell.\u003c\/p\u003e\n\u003cp\u003eIt is also the body's main handle for grabbing toxins and drug by-products so they can be excreted — most of the liver's clearance work goes through it.\u003c\/p\u003e\n\u003cp\u003eThe skin effect comes from a separate action: it interferes with the enzyme that produces dark pigment and shifts pigment production toward the lighter type.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-glutathione.png?v=1785967535\" alt=\"Glutathione molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eThe structural detail that governs glutathione's biology is the gamma linkage. The bond to cysteine forms from the side-chain gamma-carboxyl of glutamate rather than its alpha-carboxyl, and conventional aminopeptidases cannot recognise it. The only enzyme that cleaves it is gamma-glutamyl transpeptidase, on the external face of the plasma membrane. Intracellular glutathione is therefore protected from proteolysis, while extracellular glutathione must be dismantled to its constituent amino acids and reassembled inside the cell — the gamma-glutamyl cycle described by Meister and Anderson (Annu Rev Biochem, 1983). Hence millimolar cytosolic concentrations against low micromolar in plasma.\u003c\/p\u003e\n\u003cp\u003eSynthesis proceeds in two ATP-dependent steps. Glutamate-cysteine ligase, a heterodimer of catalytic and modifier subunits, forms the gamma-glutamylcysteine bond; glutathione synthetase then adds glycine. The first step is rate-limiting and feedback-inhibited by glutathione itself, with cysteine availability the usual substrate constraint. Transcription of both ligase subunits is under NRF2 control through antioxidant response elements, coupling glutathione capacity to oxidative and electrophilic stress (Lu, Biochim Biophys Acta, 2013).\u003c\/p\u003e\n\u003cp\u003eFunctionally the molecule works through its cysteine thiol. Glutathione peroxidases use it to reduce hydrogen peroxide and lipid hydroperoxides, generating the disulfide GSSG, which glutathione reductase reduces again at the cost of NADPH — a direct dependency on pentose phosphate pathway flux. Glutathione S-transferases conjugate it to electrophilic xenobiotics, initiating the mercapturic acid excretion pathway. Reversible S-glutathionylation of protein cysteines acts as a redox post-translational modification, reversed by glutaredoxins. Glutathione also recycles ascorbate and alpha-tocopherol and is the principal intracellular reservoir of cysteine.\u003c\/p\u003e\n\u003cp\u003eIts relevance to pigment research runs through a separate route: glutathione inhibits tyrosinase, partly by coordinating the copper ions at the enzyme's active site, and its thiol reacts with dopaquinone to divert melanogenesis from eumelanin toward pheomelanin. Arjinpathana and Asawanonda (J Dermatolog Treat, 2012) examined oral glutathione against placebo in a randomised, double-blind trial measuring melanin index. Adjacent compounds differ: N-acetylcysteine is a cysteine precursor acting upstream of synthesis, and GSSG is the oxidised dimer rather than the active thiol.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eYour cells hold a thousand times more than your blood\u003c\/h3\u003e\n\u003cp\u003eConcentrations are millimolar inside cells versus low micromolar in plasma — supply is an intracellular problem.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eRecycled, not used up once\u003c\/h3\u003e\n\u003cp\u003eIt is continuously restored to its active form after neutralising damage.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eProduction is self-limiting\u003c\/h3\u003e\n\u003cp\u003eThe rate-limiting enzyme is switched off by glutathione itself, so the body caps its own output.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eShifts pigment production\u003c\/h3\u003e\n\u003cp\u003eIt inhibits tyrosinase and diverts melanin synthesis toward the lighter pigment type — the basis of the skin-brightening use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eGlutathione 1500mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 5ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 5ml of water added, each 1ml (100 units) you draw = 300mg of Glutathione.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e300mg per session, 2 to 3 times per week\u003c\/td\u003e\n\u003ctd\u003e100 units (1ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e600mg per session, 2 to 3 times per week\u003c\/td\u003e\n\u003ctd\u003e100 units x 2 injections (2ml total)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose (3x weekly at 600mg): approx 8 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"pp-warn\"\u003e\u003cp\u003eFor the 600mg dose, split across 2 separate 1ml injections and rotate sites.\u003c\/p\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Any consistent time of day. Rotate injection sites with each dose.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 4 to 8 weeks.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen, thigh, or upper arm\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat does the gamma linkage actually change?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIt makes the molecule resistant to ordinary peptidases. Only gamma-glutamyl transpeptidase, an ectoenzyme on the cell surface, can break it. That single structural feature explains why intracellular glutathione persists at millimolar concentrations while circulating glutathione is rapidly dismantled.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does glutathione differ from N-acetylcysteine?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNAC is a precursor, not a substitute. It supplies cysteine, the rate-limiting substrate for glutamate-cysteine ligase, and acts upstream of glutathione synthesis. Glutathione is the finished tripeptide and the direct cofactor for peroxidase, transferase and glutaredoxin systems.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the difference between GSH and GSSG?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eGSH is the reduced form with a free cysteine thiol — the biologically active species. GSSG is the oxidised dimer, two glutathione molecules joined by a disulfide bond. The ratio between them is a standard readout of intracellular redox state, and glutathione reductase converts GSSG back to GSH using NADPH.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is it studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eResearch contexts include cellular redox buffering, phase II xenobiotic conjugation, protein S-glutathionylation as a signalling modification, hepatic oxidative stress models, and melanogenesis, where it inhibits tyrosinase and shifts melanin composition.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our \u003ca href=\"\/pages\/quality-standards\"\u003equality standards page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our \u003ca href=\"\/pages\/delivery-process\"\u003edelivery process page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the returns policy?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials in original condition may be returned within the stated window; full terms are in our \u003ca href=\"\/pages\/return-refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/skin-peptides\"\u003eAlso in Skin, Collagen \u0026amp; Cellular Renewal\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/glow\"\u003eGLOW\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/nad\"\u003eNAD+\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin \u0026amp; Anti-Ageing Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin Recovery Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What does the gamma linkage actually change?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"It makes the molecule resistant to ordinary peptidases. Only gamma-glutamyl transpeptidase, an ectoenzyme on the cell surface, can break it. That single structural feature explains why intracellular glutathione persists at millimolar concentrations while circulating glutathione is rapidly dismantled.\"}},{\"@type\":\"Question\",\"name\":\"How does glutathione differ from N-acetylcysteine?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"NAC is a precursor, not a substitute. It supplies cysteine, the rate-limiting substrate for glutamate-cysteine ligase, and acts upstream of glutathione synthesis. Glutathione is the finished tripeptide and the direct cofactor for peroxidase, transferase and glutaredoxin systems.\"}},{\"@type\":\"Question\",\"name\":\"What is the difference between GSH and GSSG?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"GSH is the reduced form with a free cysteine thiol — the biologically active species. GSSG is the oxidised dimer, two glutathione molecules joined by a disulfide bond. The ratio between them is a standard readout of intracellular redox state, and glutathione reductase converts GSSG back to GSH using NADPH.\"}},{\"@type\":\"Question\",\"name\":\"What is it studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Research contexts include cellular redox buffering, phase II xenobiotic conjugation, protein S-glutathionylation as a signalling modification, hepatic oxidative stress models, and melanogenesis, where it inhibits tyrosinase and shifts melanin composition.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our quality standards page at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our delivery process page at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"What is the returns policy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Unopened vials in original condition may be returned within the stated window; full terms are in our refund policy at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172134002911,"sku":null,"price":1500.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/Glutathione_1.png?v=1778674599"},{"product_id":"klow","title":"KLOW","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp 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.pp-step{counter-reset:s;list-style:none;padding:0;margin:0 0 18px}.pp-pdp .pp-step li{position:relative;padding:0 0 11px 34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eSkin, tissue repair and inflammation\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e2.67mg daily\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e30 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eKLOW is the GLOW blend with a fourth peptide, KPV, added. One vial contains GHK-Cu 50mg, TB-500 10mg, BPC-157 10mg and KPV 10mg.\u003c\/p\u003e\n\u003cp\u003eThree of the four target the mechanics of repair — collagen, cell movement, blood supply. KPV targets the inflammation that repair happens in. It is used where skin quality and recovery are both the goal and irritation is part of the picture.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eFour peptides in one vial: GHK-Cu, TB-500, BPC-157, KPV (80mg total)\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eSkin quality, tissue repair, inflammatory irritation\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e2.67mg once daily for 8–12 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eGHK-Cu delivers copper to the enzyme that locks collagen and elastin into mature, load-bearing fibres — the difference between making collagen and making collagen that holds.\u003c\/p\u003e\n\u003cp\u003eTB-500 handles cell movement into the area. BPC-157 handles blood supply to it.\u003c\/p\u003e\n\u003cp\u003eKPV is the piece the other three do not cover. It is a three-amino-acid fragment of a hormone your body makes, and it retains the anti-inflammatory character of the parent molecule without the pigment effects.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-ghk-cu.png?v=1785967535\" alt=\"GHK-Cu molecular structure diagram — a constituent of the KLOW blend\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eKLOW is the GLOW combination with a fourth constituent added. Three of its four peptides address the mechanics of tissue repair; the fourth addresses the inflammatory environment in which that repair takes place.\u003c\/p\u003e\n\u003cp\u003eGHK-Cu, the largest fraction at 50mg, is the tripeptide glycyl-L-histidyl-L-lysine complexed with copper(II). It binds Cu2+ with affinity comparable to serum albumin, but reversibly — accepting copper from albumin and delivering it to cellular transporters and cuproenzymes including lysyl oxidase, which cross-links collagen and elastin into mature fibrils. Pickart and Margolina (Int J Mol Sci, 2018) reported broad transcriptional modulation consistent with controlled matrix turnover rather than simple accumulation.\u003c\/p\u003e\n\u003cp\u003eTB-500 derives from thymosin beta-4, the principal G-actin sequestering peptide in mammalian cells. It binds actin monomer 1:1 through its LKKTETQ motif, maintaining a reservoir that permits rapid localised polymerisation at a migrating cell's leading edge. Malinda et al. (Journal of Investigative Dermatology, 1999) reported accelerated dermal repair in rodent models.\u003c\/p\u003e\n\u003cp\u003eBPC-157 is a 15-residue fragment of a protein isolated from human gastric juice. Hsieh et al. (Journal of Molecular Medicine, 2017) associated its pro-angiogenic activity with VEGFR2 activation and downstream Akt–eNOS signalling.\u003c\/p\u003e\n\u003cp\u003eKPV is the distinguishing constituent. It is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone — residues 11 to 13, Lys-Pro-Val — and retains the parent hormone's anti-inflammatory character without its melanocortin receptor-mediated pigmentary activity. Dalmasso et al. (Gastroenterology, 2008) reported that KPV is taken up by the intestinal di\/tripeptide transporter PepT1 and reduces inflammation in murine colitis models at low concentrations, the described intracellular effect being attenuation of NF-κB and MAP kinase signalling. Because it enters cells by an active transporter rather than a surface receptor, its pharmacology is unlike the other three.\u003c\/p\u003e\n\u003cp\u003eNo controlled study of the four-compound combination has been published.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eFour peptides, four different jobs\u003c\/h3\u003e\n\u003cp\u003eCollagen maturation, cell migration, blood supply and inflammation are handled separately.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eKPV is the differentiator vs GLOW\u003c\/h3\u003e\n\u003cp\u003eIt carries the anti-inflammatory part of alpha-MSH without the tanning activity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eFixed ratio\u003c\/h3\u003e\n\u003cp\u003eThe blend is manufactured at set quantities; the constituents cannot be dosed independently from one vial.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eNo study of the four together\u003c\/h3\u003e\n\u003cp\u003eEach constituent has its own literature; the combination itself is untested in controlled trials.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eKLOW Stack — BPC-157 10mg + TB-500 10mg + GHK-Cu 50mg + KPV 10mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 3ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 3ml of water added, each 0.1ml (10 units) you draw = 2.67mg of the total blend.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e1.33mg daily\u003c\/td\u003e\n\u003ctd\u003e5 units (0.05ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e2.67mg daily\u003c\/td\u003e\n\u003ctd\u003e10 units (0.1ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 30 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once daily, morning or evening, at a consistent time. Inject subcutaneously into the abdomen or near the area of concern.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 8 to 12 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen or inject near the area of concern\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the difference between KLOW and GLOW?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eKPV, and the total peptide content. GLOW is GHK-Cu, TB-500 and BPC-157 at 70mg total. KLOW is the same three at a published split of 50mg, 10mg and 10mg, plus 10mg of KPV, for 80mg total. KPV addresses inflammatory signalling rather than the mechanics of repair.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is KPV and why is it included?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eKPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone, residues 11 to 13. It carries the parent hormone's anti-inflammatory activity without the melanocortin receptor engagement responsible for pigmentation. Dalmasso et al. (Gastroenterology, 2008) described its uptake through the PepT1 transporter and its effect on NF-κB signalling in murine colitis models.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eIs there research on the four-compound blend itself?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo. No controlled study of these four peptides administered together has been published. The evidence base is separate preclinical work on each. The combination is a formulation convention grounded in mechanistic non-overlap and should be described as such, not as a validated protocol.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eIs the ratio of the four peptides published?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eYes. The product page states GHK-Cu 50mg, TB-500 10mg, BPC-157 10mg and KPV 10mg. This is a fixed ratio determined at manufacture and cannot be adjusted from a single vial.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our \u003ca href=\"\/pages\/quality-standards\"\u003equality standards page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our \u003ca href=\"\/pages\/delivery-process\"\u003edelivery process page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the returns policy?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials in original condition may be returned within the stated window; full terms are in our \u003ca href=\"\/pages\/return-refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/skin-peptides\"\u003eAlso in Skin, Collagen \u0026amp; Cellular Renewal\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/glow\"\u003eGLOW\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/glutathione\"\u003eGlutathione\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin \u0026amp; Anti-Ageing Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eSkin Recovery Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What is the difference between KLOW and GLOW?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"KPV, and the total peptide content. GLOW is GHK-Cu, TB-500 and BPC-157 at 70mg total. KLOW is the same three at a published split of 50mg, 10mg and 10mg, plus 10mg of KPV, for 80mg total. KPV addresses inflammatory signalling rather than the mechanics of repair.\"}},{\"@type\":\"Question\",\"name\":\"What is KPV and why is it included?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone, residues 11 to 13. It carries the parent hormone's anti-inflammatory character without the melanocortin receptor engagement responsible for pigmentation. Dalmasso et al. (Gastroenterology, 2008) described its uptake through the PepT1 transporter and its effect on NF-kB signalling in murine colitis models.\"}},{\"@type\":\"Question\",\"name\":\"Is there research on the four-compound blend itself?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No. No controlled study of these four peptides administered together has been published. The evidence base is separate preclinical work on each. The combination is a formulation convention grounded in mechanistic non-overlap and should be described as such, not as a validated protocol.\"}},{\"@type\":\"Question\",\"name\":\"Is the ratio of the four peptides published?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes. The product page states GHK-Cu 50mg, TB-500 10mg, BPC-157 10mg and KPV 10mg. This is a fixed ratio determined at manufacture and cannot be adjusted from a single vial.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch is published on our quality standards page at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our delivery process page at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"What is the returns policy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Unopened vials in original condition may be returned within the stated window; full terms are in our refund policy at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"Purist Peptides","offers":[{"title":"Default Title","offer_id":49172138459359,"sku":null,"price":139.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/KLOW.png?v=1778674608"},{"product_id":"melanotan-ii","title":"Melanotan II","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 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10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eTanning with less UV exposure\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e500mcg daily (loading)\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eLoad 10–14 days, then maintenance\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eMelanotan II is a synthetic copy of the hormone that tells your skin to produce pigment. It was developed at the University of Arizona.\u003c\/p\u003e\n\u003cp\u003ePeople use it to tan faster and with less sun exposure. It is run as a loading phase until the desired colour is reached, then dropped to two or three times a week to hold it.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA synthetic analogue of alpha-melanocyte-stimulating hormone\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eFaster tanning with reduced UV exposure\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003eLoad 250–500mcg daily for 10–14 days, then 2–3x weekly\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eYour skin already has a receptor that, when triggered, switches on pigment production. Melanotan II triggers it — and it is a much more durable molecule than the natural hormone, which is destroyed almost immediately.\u003c\/p\u003e\n\u003cp\u003eThe honest caveat: it is not selective. The same receptor family is involved in appetite and in sexual arousal pathways, which is why side effects such as nausea, flushing and appetite change are commonly reported.\u003c\/p\u003e\n\u003cp\u003eIt is not approved as a medicine in any country. Existing moles and freckles will darken along with everything else.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-melanotan-ii.png?v=1785967670\" alt=\"Melanotan II molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eMelanotan II is a synthetic analogue of alpha-melanocyte-stimulating hormone, developed at the University of Arizona from structure-activity work on the alpha-MSH core sequence. The native hormone is rapidly degraded and has little utility as a research probe. Two modifications address this. First, substitution of the L-phenylalanine at position 7 with its D-enantiomer confers resistance to proteolysis and increases potency. Second, a lactam bridge between an aspartate and a lysine side chain constrains the backbone into a cyclic conformation that approximates the bioactive shape of the native ligand, raising affinity considerably.\u003c\/p\u003e\n\u003cp\u003eThe melanocortin system comprises five G-protein-coupled receptors. MC1R is expressed on melanocytes and couples to adenylate cyclase; agonism raises cAMP, activates protein kinase A and increases transcription of microphthalmia-associated transcription factor, which in turn drives tyrosinase expression and the eumelanin synthesis pathway. MC3R and MC4R are predominantly central, concentrated in hypothalamic nuclei governing energy balance, and MC4R signalling is also implicated in central control of sexual arousal pathways. MC2R responds to ACTH in the adrenal cortex, and MC5R is associated with exocrine function.\u003c\/p\u003e\n\u003cp\u003eMelanotan II is non-selective across this family. That is the defining pharmacological property of the compound and the reason its research profile is so broad: a single molecule engages pigmentary, appetite-regulating and central arousal circuits simultaneously. It is also the reason findings are difficult to attribute to any one receptor, and the reason more selective analogues were subsequently developed — bremelanotide, an MC4R-weighted derivative, emerged from this line of work.\u003c\/p\u003e\n\u003cp\u003eThe human literature is small and early-phase. Dorr et al. (Life Sciences, 1996) reported a pilot phase I evaluation describing pigmentary responses alongside a characteristic set of adverse effects. Wessells et al. (Journal of Urology, 1998) conducted a double-blind, placebo-controlled crossover study examining erectile response in men with psychogenic erectile dysfunction.\u003c\/p\u003e\n\u003cp\u003eMelanotan II is not approved as a medicine in any jurisdiction, and case reports in the dermatological literature describe adverse events following unregulated use. Purist supplies it strictly as a laboratory reference compound.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eTriggers the skin's own pigment pathway\u003c\/h3\u003e\n\u003cp\u003eIt activates the receptor that switches on the enzyme responsible for melanin production.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eBuilt to survive in the body\u003c\/h3\u003e\n\u003cp\u003eTwo structural changes make it resist breakdown and bind far more strongly than the natural hormone.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eNot selective — that is the trade-off\u003c\/h3\u003e\n\u003cp\u003eIt also hits related receptors involved in appetite and arousal, which is where the reported side effects come from.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eNot an approved medicine anywhere\u003c\/h3\u003e\n\u003cp\u003eSupplied as a research reference compound. Nausea and flushing are commonly reported, especially when loading.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eMelanotan II 10mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 500mcg of Melanotan II.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eLoading\u003c\/td\u003e\n\u003ctd\u003e250mcg daily, 10 to 14 days\u003c\/td\u003e\n\u003ctd\u003e5 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e500mcg daily, 10 to 14 days\u003c\/td\u003e\n\u003ctd\u003e10 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMaintenance\u003c\/td\u003e\n\u003ctd\u003e250 to 500mcg, 2 to 3 times per week\u003c\/td\u003e\n\u003ctd\u003e5 to 10 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"pp-warn\"\u003e\n\u003cp\u003eLoad until desired colour is achieved, then switch to maintenance dosing.\u003c\/p\u003e\n\u003cp\u003eUV exposure during the loading phase will enhance results.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Evening preferred to minimise nausea.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e Load for 10 to 14 days, then move to maintenance as needed.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat has Melanotan II been investigated for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003ePublished research covers MC1R-mediated melanogenesis, central melanocortin signalling in appetite and energy balance, and MC4R-associated arousal pathways. Human data are limited to early-phase studies including Dorr et al. (Life Sciences, 1996) and Wessells et al. (Journal of Urology, 1998).\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat does non-selective mean in this context?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eMelanotan II binds and activates several melanocortin receptor subtypes rather than one. A single molecule therefore engages pigmentary, appetite and central arousal circuits at once, which makes attributing any observed effect to a specific receptor difficult in experimental work.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does it differ from bremelanotide?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eBremelanotide is a later derivative weighted towards MC4R activity, developed to separate central effects from MC1R-mediated pigmentary signalling. Melanotan II remains the non-selective parent compound and is used in research primarily as a broad melanocortin reference agonist.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eIs Melanotan II an approved medicine?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo. It is not approved for human use in any jurisdiction, and dermatological case reports describe adverse events following unregulated use. Purist supplies it exclusively as a laboratory reference compound for in vitro and preclinical research.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \u003ca href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \u003ca href=\"\/pages\/delivery-process\"\u003eDelivery Process\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the returns policy?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials in original condition may be returned under the conditions set out at \u003ca href=\"\/pages\/return-refund-policy\"\u003eRefund Policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/skin-peptides\"\u003eAlso in Skin, Collagen \u0026amp; Cellular Renewal\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/ghk-cu\"\u003eGHK-Cu\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/glow\"\u003eGLOW\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/klow\"\u003eKLOW\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What has Melanotan II been investigated for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Published research covers MC1R-mediated melanogenesis, central melanocortin signalling in appetite and energy balance, and MC4R-associated arousal pathways. Human data are limited to early-phase studies including Dorr et al. (Life Sciences, 1996) and Wessells et al. (Journal of Urology, 1998).\"}},{\"@type\":\"Question\",\"name\":\"What does non-selective mean in this context?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Melanotan II binds and activates several melanocortin receptor subtypes rather than one. A single molecule therefore engages pigmentary, appetite and central arousal circuits at once, which makes attributing any observed effect to a specific receptor difficult in experimental work.\"}},{\"@type\":\"Question\",\"name\":\"How does it differ from bremelanotide?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Bremelanotide is a later derivative weighted towards MC4R activity, developed to separate central effects from MC1R-mediated pigmentary signalling. Melanotan II remains the non-selective parent compound and is used in research primarily as a broad melanocortin reference agonist.\"}},{\"@type\":\"Question\",\"name\":\"Is Melanotan II an approved medicine?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No. It is not approved for human use in any jurisdiction, and dermatological case reports describe adverse events following unregulated use. Purist supplies it exclusively as a laboratory reference compound for in vitro and preclinical research.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"What is the returns policy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Unopened vials in original condition may be returned under the conditions set out at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172139245791,"sku":null,"price":39.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/MT-2_MELANOTAN_1.png?v=1778674609"}],"url":"https:\/\/puristpeptides.nl\/collections\/skin-peptides.oembed","provider":"Purist Peptides NL","version":"1.0","type":"link"}