{"title":"Weight loss Offering","description":"\u003cp\u003eStacks and products for weight loss\u003c\/p\u003e","products":[{"product_id":"mots-c","title":"MOTS-C 30mg","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 auto;padding:0 24px}.pp-pdp .pp-kick{color:var(--tl);font-size:12px;letter-spacing:2.16px;text-transform:uppercase;font-weight:600;margin:0 0 12px}.pp-pdp .pp-sec{padding:56px 0}.pp-pdp .pp-alt{background:var(--sf)}.pp-pdp .pp-sec h2{font-size:30px}.pp-pdp 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.pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eMetabolic health, energy and insulin sensitivity\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e2mg daily, 5 on\/2 off\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e5 days (10mg) \/ 4 weeks (40mg)\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eMOTS-C is unusual: it is coded by your mitochondria — the parts of the cell that make energy — rather than by the DNA in the cell nucleus.\u003c\/p\u003e\n\u003cp\u003eIt is used for metabolic health: insulin sensitivity, energy, body composition and exercise capacity. It is taken in the morning, five days on and two days off, ideally 30 to 60 minutes before training or food. Your own levels rise with exercise and fall with age, which is the basis of most of the interest in it.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA 16-amino-acid peptide encoded by mitochondrial DNA\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eInsulin sensitivity, metabolic health, energy, exercise capacity\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e2mg daily, 5 days on \/ 2 off, for 4–8 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eCells have a master switch that flips them from storing energy to burning it. MOTS-C turns that switch on.\u003c\/p\u003e\n\u003cp\u003eIt does it indirectly. Rather than binding a receptor, it shifts one metabolic pathway so that a natural activator builds up inside the cell — and that activator flips the switch.\u003c\/p\u003e\n\u003cp\u003eDownstream, mouse studies reported more glucose taken into muscle without needing extra insulin, more fat burned, and resistance to diet-induced weight gain.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-mots-c.png?v=1785967535\" alt=\"MOTS-C molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eMOTS-C belongs to a small class of mitochondrial-derived peptides — short open reading frames encoded within mitochondrial ribosomal RNA genes rather than nuclear DNA. Humanin and the SHLP series arise from the 16S rRNA gene; MOTS-C from the 12S. Lee et al. (Cell Metabolism, 2015) identified the peptide, showed it circulates, and characterised its metabolic activity.\u003c\/p\u003e\n\u003cp\u003eIts mechanism is indirect and unusual. Rather than binding a cell-surface receptor, MOTS-C acts on the folate-methionine one-carbon cycle, suppressing flux through de novo purine biosynthesis. The consequence is accumulation of AICAR — 5-aminoimidazole-4-carboxamide ribonucleotide — an endogenous intermediate that allosterically activates AMP-activated protein kinase. AMPK activation is therefore downstream of a metabolite shift rather than of direct binding, which separates MOTS-C from biguanides such as metformin, which raise the AMP:ATP ratio by inhibiting respiratory complex I, and from direct AMPK agonists.\u003c\/p\u003e\n\u003cp\u003eOnce AMPK is engaged the profile is conventional catabolic signalling: increased GLUT4 translocation and insulin-independent glucose uptake in skeletal muscle, increased fatty acid oxidation, and suppression of lipogenic and gluconeogenic programmes. In the original mouse work this presented as resistance to diet-induced obesity and improved insulin sensitivity.\u003c\/p\u003e\n\u003cp\u003eMOTS-C also has a nuclear role. Kim et al. (Cell Metabolism, 2018) reported that under metabolic stress the peptide translocates to the nucleus, associates with stress-responsive transcription factors and regulates antioxidant response element-driven genes. That gives it a retrograde signalling function — mitochondria issuing adaptive instructions to the nuclear genome — and it is the feature drawing most current research attention.\u003c\/p\u003e\n\u003cp\u003eReynolds et al. (Nature Communications, 2021) characterised MOTS-C as exercise-responsive: circulating and skeletal muscle levels rise with exercise in humans, and administration to aged mice improved measures of physical capacity and muscle homeostasis. That work underlies its description as an exercise-mimetic in the literature. Endogenous levels decline with age, and a mitochondrial DNA variant altering the peptide sequence has been examined in relation to longevity in East Asian cohorts.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eMade by your mitochondria\u003c\/h3\u003e\n\u003cp\u003eOne of a small group of peptides coded in mitochondrial DNA rather than the cell nucleus.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eTurns on the cell's energy-burning switch\u003c\/h3\u003e\n\u003cp\u003eIt activates AMPK — the master regulator that shifts cells from storing to burning fuel.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eImproved insulin sensitivity in mice\u003c\/h3\u003e\n\u003cp\u003eThe original work reported better glucose handling and resistance to diet-induced obesity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eRises with exercise in humans\u003c\/h3\u003e\n\u003cp\u003eHuman levels increase with exercise; ageing mice given it showed improved physical capacity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eMOTS-C 10mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 1ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 1ml of water added, each 0.1ml (10 units) you draw = 1mg of MOTS-C.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e2mg daily\u003c\/td\u003e\n\u003ctd\u003e20 units (0.2ml)\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 5 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Morning preferred, 30 to 60 minutes before exercise or food. 5 days on, 2 days off.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 4 to 8 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eMOTS-C 40mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 2mg of MOTS-C.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e2mg daily\u003c\/td\u003e\n\u003ctd\u003e10 units (0.1ml)\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 4 weeks\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Morning preferred, 30 to 60 minutes before exercise or food. 5 days on, 2 days off.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 4 to 8 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat makes MOTS-C different from other peptides?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIts origin. Almost all research peptides are fragments or analogues of nuclear-encoded proteins. MOTS-C is transcribed from mitochondrial DNA, within the 12S rRNA gene, which places it in the small class of mitochondrial-derived peptides alongside humanin and the SHLPs.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eDoes MOTS-C bind a receptor?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo specific cell-surface receptor has been established. The characterised mechanism is metabolic: inhibition of folate-cycle flux, accumulation of AICAR, and consequent AMPK activation. Its nuclear translocation under stress is a separate, intracellular mode of action.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is it described as an exercise mimetic?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eReynolds et al. (Nature Communications, 2021) showed that MOTS-C rises in muscle and plasma following exercise, and that administering it to aged mice improved measures of running capacity and muscle homeostasis. The term describes an overlap in signalling, not an equivalence to training.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the difference between the 10mg and 40mg vials?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003ePeptide mass only; the material is from the same synthesis and assay standard. The 40mg vial is intended for extended experimental series and gives a higher concentration for a given diluent volume.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our \u003ca href=\"\/pages\/quality-standards\"\u003equality standards page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our \u003ca href=\"\/pages\/delivery-process\"\u003edelivery process page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the returns policy?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials in original condition may be returned within the stated window; full terms are in our \u003ca href=\"\/pages\/return-refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/energy-mitochondrial-peptides\"\u003eAlso in Cellular Energy \u0026amp; Mitochondrial\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/nad\"\u003eNAD+\u003c\/a\u003eRetatrutide\u003ca class=\"pp-chip\" href=\"\/products\/cjc-1295-w-dac\"\u003eCJC-1295 w DAC\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/cellular-longevity-peptide-stack\"\u003eCellular Longevity Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eMetabolic Reset Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eFat Loss Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/lean-growth-peptide-stack\"\u003eLean Growth Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What makes MOTS-C different from other peptides?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Its origin. Almost all research peptides are fragments or analogues of nuclear-encoded proteins. MOTS-C is transcribed from mitochondrial DNA, within the 12S rRNA gene, which places it in the small class of mitochondrial-derived peptides alongside humanin and the SHLPs.\"}},{\"@type\":\"Question\",\"name\":\"Does MOTS-C bind a receptor?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No specific cell-surface receptor has been established. The characterised mechanism is metabolic: inhibition of folate-cycle flux, accumulation of AICAR, and consequent AMPK activation. Its nuclear translocation under stress is a separate, intracellular mode of action.\"}},{\"@type\":\"Question\",\"name\":\"How is it described as an exercise mimetic?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Reynolds et al. (Nature Communications, 2021) showed that MOTS-C rises in muscle and plasma following exercise, and that administering it to aged mice improved measures of running capacity and muscle homeostasis. The term describes an overlap in signalling, not an equivalence to training.\"}},{\"@type\":\"Question\",\"name\":\"What is the difference between the 10mg and 40mg vials?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Peptide mass only; the material is from the same synthesis and assay standard. The 40mg vial is intended for extended experimental series and gives a higher concentration for a given diluent volume.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our quality standards page at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Full timelines are set out on our delivery process page at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"What is the returns policy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Unopened vials in original condition may be returned within the stated window; full terms are in our refund policy at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172141736159,"sku":null,"price":79.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/ChatGPT_Image_May_20_2026_11_51_43_PM.png?v=1779301325"},{"product_id":"tesamorelin","title":"Tesamorelin 20mg","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 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10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eVisceral (deep abdominal) fat reduction\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e2mg daily\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e10 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eTesamorelin is a stabilised version of the brain signal that tells the pituitary to release growth hormone. It is the only compound in this category with regulatory approval anywhere — approved in the US for a specific HIV-related condition.\u003c\/p\u003e\n\u003cp\u003eIt is used for visceral fat: the deep abdominal fat that sits around the organs, as distinct from the fat you can pinch. That distinction is the whole reason people choose it.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA stabilised analogue of growth hormone-releasing hormone\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eReducing visceral (deep abdominal) fat\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e2mg once daily in the evening, 8–12 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eIt works on your pituitary, prompting it to release more of your own growth hormone — rather than injecting growth hormone directly.\u003c\/p\u003e\n\u003cp\u003eThat matters. Because the release is still your body's own pulsing system, your natural feedback brakes stay in place instead of being overridden.\u003c\/p\u003e\n\u003cp\u003eThe growth hormone then raises fat-breakdown activity. Visceral fat carries more growth hormone receptors than fat under the skin and responds more strongly, which is why the effect shows up there first.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-tesamorelin.png?v=1785967669\" alt=\"Tesamorelin molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eTesamorelin is a stabilised analogue of human growth hormone-releasing hormone. The native molecule, GHRH(1-44), is rapidly inactivated in circulation by dipeptidyl peptidase-4, which cleaves the N-terminal dipeptide and abolishes receptor activity. Tesamorelin carries a trans-3-hexenoyl group attached to the N-terminal tyrosine, which sterically obstructs that cleavage and materially extends the functional half-life while preserving affinity for the receptor.\u003c\/p\u003e\n\u003cp\u003eThe target is the GHRH receptor, a class B G-protein-coupled receptor expressed on pituitary somatotrophs. Agonism raises intracellular cAMP, activates protein kinase A, and increases both the synthesis and the pulsatile release of endogenous growth hormone. This is the mechanistically important distinction from exogenous recombinant growth hormone: tesamorelin amplifies the animal's own secretory pulses rather than imposing a continuous exogenous concentration, so the pituitary's negative feedback loops — somatostatin tone and IGF-1 feedback — remain intact and continue to constrain the response.\u003c\/p\u003e\n\u003cp\u003eDownstream, elevated growth hormone acts on hepatic and peripheral GH receptors, raising IGF-1 and increasing hormone-sensitive lipase activity in adipose tissue. Visceral adipose tissue is comparatively rich in GH receptors and lipolytically responsive, which is the mechanistic basis for the tissue-selective findings reported in the clinical literature.\u003c\/p\u003e\n\u003cp\u003eThat literature is unusually solid for this compound class. Falutz et al. (New England Journal of Medicine, 2007) reported reductions in visceral adipose tissue in a randomised placebo-controlled trial in patients with HIV-associated excess abdominal fat, findings extended in a pooled analysis of two phase 3 trials. Stanley et al. (Lancet HIV, 2019) subsequently reported effects on hepatic fat in a randomised, double-blind, multicentre trial of non-alcoholic fatty liver disease in HIV.\u003c\/p\u003e\n\u003cp\u003eTesamorelin differs from growth hormone secretagogues such as ipamorelin, which act at the ghrelin receptor (GHS-R1a) rather than the GHRH receptor. The two pathways are distinct and, in research models, additive; CJC-1295 is the closer comparator, being a GHRH analogue of different design.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eTargets deep abdominal fat\u003c\/h3\u003e\n\u003cp\u003eVisceral fat is richer in growth hormone receptors and more responsive, which is why results concentrate there.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eUses your own hormone release\u003c\/h3\u003e\n\u003cp\u003eIt amplifies the pituitary's natural pulses rather than replacing them with a flat exogenous dose.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eBacked by a NEJM trial\u003c\/h3\u003e\n\u003cp\u003eVisceral fat reduction was reported in a New England Journal of Medicine randomised trial.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eAlso studied for liver fat\u003c\/h3\u003e\n\u003cp\u003eA randomised trial published in Lancet HIV examined its effect on fat in the liver.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eTesamorelin 20mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 1mg of Tesamorelin.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e1mg daily\u003c\/td\u003e\n\u003ctd\u003e10 units (0.1ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e2mg daily\u003c\/td\u003e\n\u003ctd\u003e20 units (0.2ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 10 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Evening preferred, at least 2 hours after your last meal. This aligns with the body's natural growth hormone release during sleep.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 8 to 12 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does tesamorelin differ from exogenous growth hormone?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eRecombinant growth hormone supplies the hormone directly, overriding pituitary regulation. Tesamorelin acts one step upstream at the GHRH receptor, amplifying the pituitary's own pulsatile secretion. Somatostatin tone and IGF-1 negative feedback remain intact, so the physiological pattern of release is preserved in research models.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does it differ from ipamorelin or CJC-1295?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIpamorelin is a ghrelin receptor (GHS-R1a) agonist — a different receptor and a different pathway. CJC-1295 is the closer comparator, being a GHRH analogue, though of different structural design. Tesamorelin is the GHRH analogue with the most substantial randomised controlled trial literature behind it.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat has tesamorelin been studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIts principal published trials examined visceral adipose tissue in HIV-associated lipodystrophy (Falutz et al., NEJM, 2007, and a pooled phase 3 analysis) and hepatic fat in non-alcoholic fatty liver disease in HIV (Stanley et al., Lancet HIV, 2019). Purist supplies the compound for laboratory research only.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is visceral fat a distinct research target?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eVisceral adipose tissue differs from subcutaneous fat in receptor density, lipolytic responsiveness and metabolic activity. It is comparatively rich in growth hormone receptors, which is the mechanistic basis for the tissue-selective effects reported in the tesamorelin trials.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \u003ca href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \u003ca href=\"\/pages\/delivery-process\"\u003eDelivery Process\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eCan I return an order?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnder the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out in our \u003ca href=\"\/pages\/return-refund-policy\"\u003eRefund Policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/fat-loss-peptides\"\u003eAlso in Fat Loss \u0026amp; Metabolic Research\u003c\/a\u003eRetatrutide\u003ca class=\"pp-chip\" href=\"\/products\/cjc-1295-w-dac\"\u003eCJC-1295 w DAC\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eVisceral Fat Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/gh-optimisation-peptide-stack\"\u003eGH Optimisation Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/peptide-stacks\"\u003eMetabolic Reset Peptide Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"How does tesamorelin differ from exogenous growth hormone?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Recombinant growth hormone supplies the hormone directly, overriding pituitary regulation. Tesamorelin acts one step upstream at the GHRH receptor, amplifying the pituitary's own pulsatile secretion. Somatostatin tone and IGF-1 negative feedback remain intact, so the physiological pattern of release is preserved in research models.\"}},{\"@type\":\"Question\",\"name\":\"How does it differ from ipamorelin or CJC-1295?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Ipamorelin is a ghrelin receptor (GHS-R1a) agonist, a different receptor and a different pathway. CJC-1295 is the closer comparator, being a GHRH analogue, though of different structural design. Tesamorelin is the GHRH analogue with the most substantial randomised controlled trial literature behind it.\"}},{\"@type\":\"Question\",\"name\":\"What has tesamorelin been studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Its principal published trials examined visceral adipose tissue in HIV-associated lipodystrophy (Falutz et al., NEJM, 2007, and a pooled phase 3 analysis) and hepatic fat in non-alcoholic fatty liver disease in HIV (Stanley et al., Lancet HIV, 2019). Purist supplies the compound for laboratory research only.\"}},{\"@type\":\"Question\",\"name\":\"Why is visceral fat a distinct research target?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Visceral adipose tissue differs from subcutaneous fat in receptor density, lipolytic responsiveness and metabolic activity. It is comparatively rich in growth hormone receptors, which is the mechanistic basis for the tissue-selective effects reported in the tesamorelin trials.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"Can I return an order?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Under the EU Consumer Rights Directive you may withdraw from your order within 14 days of delivery, without giving a reason, provided the vial's seal is intact. Vials that have been unsealed, opened, punctured or reconstituted cannot be returned, as sterility and integrity can no longer be assured (Article 16(e)). If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":49172150354143,"sku":null,"price":59.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/TESAMORELIN.png?v=1778674630"},{"product_id":"lean-growth-peptide-stack","title":"Lean Growth Stack — Complete 8-Week Cycle","description":"\u003cp\u003eThe lean muscle peptide stack pairs CJC-1295 w DAC with MOTS-C as a complete 8-week research cycle, targeting lean growth from both the hormonal (GH axis) and cellular energy (mitochondrial) angles.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhat's in this cycle\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e2 × CJC-1295 w DAC 5mg — covers 10 weeks; 2mg spare\u003c\/li\u003e\n\u003cli\u003e2 × MOTS-C 40mg — covers exactly 8 weeks at 10mg\/week\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eRetail if bought as separate vials: €279.80. Bundle price €251.82 — you save €27.98 (10%).\u003c\/p\u003e\u003cp\u003e\u003ca href=\"\/pages\/lean-growth-peptide-stack\"\u003eFull protocol, dosing and reconstitution guide →\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003e\u003cem\u003eResearch use only. Not for human or veterinary consumption.\u003c\/em\u003e\u003c\/p\u003e","brand":"Purist Peptides","offers":[{"title":"Default Title","offer_id":51362497429727,"sku":"PP-STK-04","price":251.82,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/purist-peptides-lean-growth-peptide-stack-complete-8-week-cycle_5445ac68-41b3-41e8-b897-1e5f04c9d104.jpg?v=1789020502"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/collections\/hf_20260313_191709_4f43738e-950f-4738-b32e-59e5f6decda6.png?v=1789020867","url":"https:\/\/puristpeptides.nl\/collections\/weight-loss-offering.oembed","provider":"Purist Peptides NL","version":"1.0","type":"link"}