{"product_id":"ghost","title":"ghost","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 auto;padding:0 24px}.pp-pdp .pp-kick{color:var(--tl);font-size:12px;letter-spacing:2.16px;text-transform:uppercase;font-weight:600;margin:0 0 12px}.pp-pdp .pp-sec{padding:56px 0}.pp-pdp .pp-alt{background:var(--sf)}.pp-pdp .pp-sec h2{font-size:30px}.pp-pdp .pp-prose p{font-size:15.5px;color:var(--mut)}.pp-pdp .pp-prose p strong{color:var(--nv)}.pp-pdp .pp-wide{max-width:900px}.pp-pdp 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18px}.pp-pdp .pp-facts .pp-in{grid-template-columns:repeat(2,1fr);gap:18px}.pp-pdp .pp-fi{border-left:0;text-align:left;padding:0}.pp-pdp .pp-fi .pp-v1{font-size:22px}.pp-pdp .pp-cards{grid-template-columns:1fr} } @media(max-width:520px){.pp-pdp .pp-facts .pp-in{grid-template-columns:1fr}}.pp-pdp .pp-ov{border-left:4px solid var(--tl);background:var(--sf);border-radius:0 12px 12px 0;padding:26px 28px;max-width:900px}.pp-pdp .pp-ov p{font-size:16px;color:var(--ink)}.pp-pdp .pp-tldr{list-style:none;margin:18px 0 0;padding:16px 0 0;border-top:1px solid var(--ln)}.pp-pdp .pp-tldr li{display:flex;gap:14px;padding:6px 0;font-size:14.5px;color:var(--mut)}.pp-pdp .pp-tldr b{color:var(--nv);flex:0 0 148px}.pp-pdp .pp-card h3{font-size:15.5px;margin:0 0 8px;color:var(--nv);line-height:1.3}.pp-pdp .pp-more{margin-top:24px;max-width:900px}.pp-pdp .pp-more .pp-ab p{margin-bottom:12px}.pp-pdp .pp-dose{width:100%;border-collapse:collapse;margin:0 0 16px}.pp-pdp .pp-dose th,.pp-pdp .pp-dose td{text-align:left;padding:11px 14px;border-bottom:1px solid var(--ln);font-size:14.5px;color:var(--mut)}.pp-pdp .pp-dose th{background:var(--nv);color:#fff;font-size:11.5px;letter-spacing:1.2px;text-transform:uppercase;font-weight:700}.pp-pdp .pp-dose td:first-child{font-weight:700;color:var(--nv);white-space:nowrap}.pp-pdp .pp-step{counter-reset:s;list-style:none;padding:0;margin:0 0 18px}.pp-pdp .pp-step li{position:relative;padding:0 0 11px 34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eWeight loss — triple receptor action\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e1mg → 9mg weekly\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eTitrated over 8+ weeks\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eRetatrutide is the newest generation of weight-loss compound. Where semaglutide hits one receptor and tirzepatide hits two, retatrutide hits three.\u003c\/p\u003e\n\u003cp\u003eThe third one is the difference. GLP-1 and GIP reduce how much you eat; the glucagon receptor increases how much energy you burn. It is a once-weekly injection, titrated up slowly over about eight weeks.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA single molecule acting on GLP-1, GIP and glucagon receptors\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eWeight loss and metabolic health\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003eOnce weekly, titrated 1mg → 9mg over 8+ weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eTwo of the three receptors work on the intake side: less appetite, slower stomach emptying, better insulin response to food. This is the same territory as semaglutide and tirzepatide.\u003c\/p\u003e\n\u003cp\u003eThe third — the glucagon receptor — works on the output side, in the liver, increasing energy expenditure and fat burning. That is what neither of the others does.\u003c\/p\u003e\n\u003cp\u003eTitrate slowly. The gastrointestinal side effects are dose-related, and there is no requirement to reach the top dose if a lower one is working.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-retatrutide.png?v=1785967669\" alt=\"Retatrutide molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eRetatrutide is a unimolecular agonist at three class B G-protein-coupled receptors: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). Each is coupled principally to Gs, so agonism at all three raises intracellular cAMP in the relevant target tissues, but the tissue distribution of the three receptors is what produces the compound's distinct profile.\u003c\/p\u003e\n\u003cp\u003eGLP-1R agonism acts on pancreatic beta cells to potentiate glucose-dependent insulin secretion, and on hindbrain and hypothalamic circuits governing satiety and gastric emptying. GIPR signalling contributes a further incretin effect at the beta cell and has additional actions in adipose tissue; its role in energy balance remains an area of active argument, since both GIPR agonism and antagonism have shown weight-lowering effects in different models. The glucagon receptor arm is the substantive point of difference. GCGR is expressed densely in hepatocytes, where cAMP-driven signalling raises hepatic lipid oxidation and energy expenditure. In principle this adds a catabolic, expenditure-side mechanism to the intake-side mechanisms supplied by GLP-1R and GIPR — a different axis of action from dual GIP\/GLP-1 agonists such as tirzepatide, which lack glucagon receptor activity, and from selective GLP-1 agonists such as semaglutide.\u003c\/p\u003e\n\u003cp\u003eThe counterweight is that unopposed glucagon receptor agonism is hyperglycaemic. The design problem for triple agonists is therefore ratio: the incretin components must be sufficient to offset the glycaemic consequence of the glucagon component. Retatrutide's receptor potency ratios were selected on this basis.\u003c\/p\u003e\n\u003cp\u003eStructurally, retatrutide is a synthetic peptide carrying a fatty diacid substitution that promotes reversible albumin binding, extending circulating half-life sufficiently for once-weekly administration in the clinical protocols in which it was studied. Non-canonical residues in the backbone reduce susceptibility to dipeptidyl peptidase-4 cleavage.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eThree receptors, one molecule\u003c\/h3\u003e\n\u003cp\u003eGLP-1 and GIP reduce intake; the glucagon arm raises energy expenditure.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003ePhase 2 obesity trial in NEJM\u003c\/h3\u003e\n\u003cp\u003eResults were published in the New England Journal of Medicine in 2023.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eAlso trialled in type 2 diabetes\u003c\/h3\u003e\n\u003cp\u003eA separate phase 2 trial was published in The Lancet in 2023.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eThe glucagon arm is the differentiator\u003c\/h3\u003e\n\u003cp\u003eDual GIP\/GLP-1 agonists such as tirzepatide have no glucagon receptor activity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eRetatrutide 30mg (GLP-3RT)\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 3ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 3ml of water added, each 0.1ml (10 units) you draw = 1mg of Retatrutide.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeek 1\u003c\/td\u003e\n\u003ctd\u003e1mg once weekly\u003c\/td\u003e\n\u003ctd\u003e10 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeek 2\u003c\/td\u003e\n\u003ctd\u003e1.5mg once weekly\u003c\/td\u003e\n\u003ctd\u003e15 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 3 to 4\u003c\/td\u003e\n\u003ctd\u003e3mg once weekly\u003c\/td\u003e\n\u003ctd\u003e30 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 5 to 6\u003c\/td\u003e\n\u003ctd\u003e4.5mg once weekly\u003c\/td\u003e\n\u003ctd\u003e45 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 7 to 8\u003c\/td\u003e\n\u003ctd\u003e6mg once weekly\u003c\/td\u003e\n\u003ctd\u003e60 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeek 9 onwards\u003c\/td\u003e\n\u003ctd\u003e9mg (peak) once weekly\u003c\/td\u003e\n\u003ctd\u003e90 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"pp-warn\"\u003e\n\u003cp\u003eThis 30mg schedule is the gentler ramp, intended for a first cycle.\u003c\/p\u003e\n\u003cp\u003eProgress through each step only when comfortable at the current dose.\u003c\/p\u003e\n\u003cp\u003eThere is no requirement to reach the peak dose. Stay at the dose that works for you.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once weekly on the same day each week.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e Continue at your comfortable maintenance dose for as long as needed. Reassess regularly.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eRetatrutide 60mg (GLP-3RT)\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 3mg of Retatrutide.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 1 to 2\u003c\/td\u003e\n\u003ctd\u003e1.5mg once weekly\u003c\/td\u003e\n\u003ctd\u003e5 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 3 to 4\u003c\/td\u003e\n\u003ctd\u003e3mg once weekly\u003c\/td\u003e\n\u003ctd\u003e10 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 5 to 6\u003c\/td\u003e\n\u003ctd\u003e6mg once weekly\u003c\/td\u003e\n\u003ctd\u003e20 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 7 to 8\u003c\/td\u003e\n\u003ctd\u003e9mg once weekly\u003c\/td\u003e\n\u003ctd\u003e30 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeek 9 onwards\u003c\/td\u003e\n\u003ctd\u003e12mg (peak) once weekly\u003c\/td\u003e\n\u003ctd\u003e40 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"pp-warn\"\u003e\n\u003cp\u003eThe 60mg schedule starts higher and peaks higher. It is intended for someone who has already completed a cycle, not for a first course.\u003c\/p\u003e\n\u003cp\u003eProgress through each step only when comfortable at the current dose.\u003c\/p\u003e\n\u003cp\u003eThere is no requirement to reach the peak dose. Stay at the dose that works for you.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once weekly on the same day each week.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e Continue at your comfortable maintenance dose for as long as needed. Reassess regularly.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat distinguishes retatrutide from tirzepatide?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eTirzepatide is a dual agonist at the GIP and GLP-1 receptors. Retatrutide adds agonism at the glucagon receptor, which is expressed principally in the liver and is associated in research models with increased hepatic lipid oxidation and energy expenditure. The two compounds therefore differ in mechanism, not only in potency.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat has retatrutide been studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIts published phase 2 programme covered obesity (Jastreboff et al., NEJM 2023) and type 2 diabetes (Rosenstock et al., Lancet 2023). Substudies have examined body composition change. Later-phase trials under the TRANSCEND programme have been reported. Purist supplies the compound for laboratory research only.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy does the glucagon receptor component matter?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eGlucagon receptor agonism on its own raises blood glucose. In a triple agonist the incretin components are intended to offset that effect, so the receptor potency ratio is a central design parameter. This balance is the principal subject of interest in the triple-agonist literature.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eIs the 60mg vial a different compound to the 30mg vial?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo. Both vials contain the same lyophilised compound; they differ only in the mass supplied. The larger vial reduces the number of reconstitutions required across an extended research protocol.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \u003ca href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands, with timelines varying by region and courier. Current dispatch and transit windows are set out at \u003ca href=\"\/pages\/delivery-process\"\u003eDelivery Process\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eCan I return an order?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials with the seal intact may be returned within 14 days of delivery under the EU right of withdrawal; vials that have been unsealed, opened or reconstituted cannot be returned. If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out in our \u003ca href=\"\/pages\/return-refund-policy\"\u003eRefund Policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/fat-loss-peptides\"\u003eAlso in Fat Loss \u0026amp; Metabolic Research\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/tesamorelin\"\u003eTesamorelin\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/mots-c\"\u003eMOTS-C\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/aod-9604\"\u003eAOD 9604\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/fat-loss-peptide-stack\"\u003eFat Loss Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/visceral-fat-peptide-stack\"\u003eVisceral Fat Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/metabolic-reset-peptide-stack\"\u003eMetabolic Reset Peptide Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What distinguishes retatrutide from tirzepatide?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Tirzepatide is a dual agonist at the GIP and GLP-1 receptors. Retatrutide adds agonism at the glucagon receptor, which is expressed principally in the liver and is associated in research models with increased hepatic lipid oxidation and energy expenditure. The two compounds therefore differ in mechanism, not only in potency.\"}},{\"@type\":\"Question\",\"name\":\"What has retatrutide been studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Its published phase 2 programme covered obesity (Jastreboff et al., NEJM 2023) and type 2 diabetes (Rosenstock et al., Lancet 2023). Substudies have examined body composition change. Later-phase trials under the TRANSCEND programme have been reported. Purist supplies the compound for laboratory research only.\"}},{\"@type\":\"Question\",\"name\":\"Why does the glucagon receptor component matter?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Glucagon receptor agonism on its own raises blood glucose. In a triple agonist the incretin components are intended to offset that effect, so the receptor potency ratio is a central design parameter. This balance is the principal subject of interest in the triple-agonist literature.\"}},{\"@type\":\"Question\",\"name\":\"Is the 60mg vial a different compound to the 30mg vial?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No. Both vials contain the same lyophilised compound; they differ only in the mass supplied. The larger vial reduces the number of reconstitutions required across an extended research protocol.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at https:\/\/puristpeptides.nl\/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from the Netherlands, with timelines varying by region and courier. Current dispatch and transit windows are set out at https:\/\/puristpeptides.nl\/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"Can I return an order?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Unopened vials with the seal intact may be returned within 14 days of delivery under the EU right of withdrawal; vials that have been unsealed, opened or reconstituted cannot be returned. If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out at https:\/\/puristpeptides.nl\/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"Purist Peptides","offers":[{"title":"30mg","offer_id":51378450333919,"sku":"PP-RETA-30","price":0.0,"currency_code":"EUR","in_stock":false},{"title":"60mg","offer_id":51378450366687,"sku":"PP-RETA-60","price":0.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/8787\/3759\/files\/purist-peptides-retatrutide-30mg-glp1-gip-glucagon-research-peptide.jpg?v=1789020820","url":"https:\/\/puristpeptides.nl\/products\/ghost","provider":"Purist Peptides NL","version":"1.0","type":"link"}