{"product_id":"semax","title":"Semax","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 auto;padding:0 24px}.pp-pdp .pp-kick{color:var(--tl);font-size:12px;letter-spacing:2.16px;text-transform:uppercase;font-weight:600;margin:0 0 12px}.pp-pdp .pp-sec{padding:56px 0}.pp-pdp .pp-alt{background:var(--sf)}.pp-pdp .pp-sec h2{font-size:30px}.pp-pdp .pp-prose p{font-size:15.5px;color:var(--mut)}.pp-pdp .pp-prose p strong{color:var(--nv)}.pp-pdp .pp-wide{max-width:900px}.pp-pdp 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td{text-align:left;padding:11px 14px;border-bottom:1px solid var(--ln);font-size:14.5px;color:var(--mut)}.pp-pdp .pp-dose th{background:var(--nv);color:#fff;font-size:11.5px;letter-spacing:1.2px;text-transform:uppercase;font-weight:700}.pp-pdp .pp-dose td:first-child{font-weight:700;color:var(--nv);white-space:nowrap}.pp-pdp .pp-step{counter-reset:s;list-style:none;padding:0;margin:0 0 18px}.pp-pdp .pp-step li{position:relative;padding:0 0 11px 34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eNeurotrophic signalling research\u003c\/b\u003e\u003cspan\u003eResearch area\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e10mg\u003c\/b\u003e\u003cspan\u003ePer vial\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eACTH(4–10) analogue\u003c\/b\u003e\u003cspan\u003eStructure\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eSemax is a synthetic seven-amino-acid peptide (Met-Glu-His-Phe-Pro-Gly-Pro) developed in Russia. It is an analogue of ACTH(4–10), a short fragment of the pituitary hormone adrenocorticotropin.\u003c\/p\u003e\n\u003cp\u003eIt is studied in preclinical and clinical research for its effects on BDNF expression and neurotrophic signalling, and in cognitive-function models. Strictly for laboratory research use. Not for human or veterinary consumption.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA synthetic heptapeptide analogue of the ACTH(4–10) fragment\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly studied for\u003c\/b\u003e\u003cspan\u003eBDNF expression, neurotrophic signalling, cognitive-function models\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eResearch protocol\u003c\/b\u003e\u003cspan\u003eTo be published shortly. Contact us for details\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eSemax keeps the first four residues of the ACTH(4–10) fragment (Met-Glu-His-Phe) and ends in a Pro-Gly-Pro extension at the C-terminus.\u003c\/p\u003e\n\u003cp\u003eThat extension was added to improve stability: short peptides are broken down quickly by peptidases, and the Pro-Gly-Pro tail slows that breakdown.\u003c\/p\u003e\n\u003cp\u003eResearch interest centres on neurotrophic signalling, in particular the expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eSemax was developed in Russia as part of a research programme on short regulatory peptides derived from adrenocorticotropic hormone (ACTH). The ACTH(4–10) fragment had attracted interest because it retains activity in central nervous system models while lacking the adrenal-stimulating role of the full hormone.\u003c\/p\u003e\n\u003cp\u003eThe native fragment is short-lived in biological systems. Semax addresses this by retaining the N-terminal Met-Glu-His-Phe sequence and adding a C-terminal Pro-Gly-Pro extension, a motif chosen to improve resistance to enzymatic degradation. The result is a heptapeptide: Met-Glu-His-Phe-Pro-Gly-Pro.\u003c\/p\u003e\n\u003cp\u003eThe most cited mechanistic work concerns neurotrophins. Studies in rodents have reported changes in the expression of brain-derived neurotrophic factor (BDNF) and its high-affinity receptor TrkB in hippocampal tissue following Semax administration, and gene-expression studies have examined broader transcriptional responses in brain tissue.\u003c\/p\u003e\n\u003cp\u003eFunctional studies have used learning and memory paradigms in rodent cognitive-function models. As with many peptides from this research tradition, a large share of the literature comes from Russian research groups, and independent replication outside that setting is more limited.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eBuilt on a hormone fragment\u003c\/h3\u003e\n\u003cp\u003eSemax is an analogue of ACTH(4–10), a short fragment of adrenocorticotropic hormone.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eStabilised by Pro-Gly-Pro\u003c\/h3\u003e\n\u003cp\u003eA C-terminal Pro-Gly-Pro extension was added to slow enzymatic breakdown.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eBDNF and TrkB signalling\u003c\/h3\u003e\n\u003cp\u003eRodent studies report changes in BDNF and TrkB expression in brain tissue.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eStudied in cognitive-function models\u003c\/h3\u003e\n\u003cp\u003eLearning and memory paradigms in rodents are a recurring research model.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eReconstitution and research protocol for this compound will be published here shortly. Contact us for details.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eStrictly for laboratory research use. Not for human or veterinary consumption.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is Semax studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003ePublished work covers BDNF expression and neurotrophic signalling, gene-expression responses in brain tissue, and learning and memory performance in rodent cognitive-function models. Much of the literature originates from Russian research groups. Purist supplies the compound for laboratory research only.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does Semax relate to ACTH?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eSemax is an analogue of ACTH(4–10), a short fragment of adrenocorticotropic hormone. It keeps the fragment’s N-terminal Met-Glu-His-Phe sequence and replaces the remainder with a Pro-Gly-Pro extension.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy does Semax carry a Pro-Gly-Pro extension?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eShort peptides are rapidly degraded by peptidases. The Pro-Gly-Pro C-terminal extension was added to improve stability against that breakdown in experimental systems. Selank carries the same extension.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does Semax differ from Selank?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eBoth are synthetic heptapeptides developed in Russia that end in Pro-Gly-Pro. Semax is derived from the ACTH(4–10) fragment and is researched mainly for neurotrophic signalling; Selank is derived from tuftsin and is researched mainly for GABAergic signalling.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by independent HPLC at Bioindustrial Services. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \u003ca href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \u003ca href=\"\/pages\/delivery-process\"\u003eDelivery Process\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the returns policy?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials in original condition may be returned under the conditions set out at \u003ca href=\"\/pages\/return-refund-policy\"\u003eRefund Policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/sleep-mood-peptides\"\u003eAlso in Sleep, Stress \u0026amp; Circadian\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/selank\"\u003eSelank\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/dsip\"\u003eDSIP\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/collections\/all-peptides\"\u003eThe Full Purist Range\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"What is Semax studied for?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Published work covers BDNF expression and neurotrophic signalling, gene-expression responses in brain tissue, and learning and memory performance in rodent cognitive-function models. Much of the literature originates from Russian research groups. Purist supplies the compound for laboratory research only.\"}}, {\"@type\": \"Question\", \"name\": \"How does Semax relate to ACTH?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Semax is an analogue of ACTH(4–10), a short fragment of adrenocorticotropic hormone. It keeps the fragment’s N-terminal Met-Glu-His-Phe sequence and replaces the remainder with a Pro-Gly-Pro extension.\"}}, {\"@type\": \"Question\", \"name\": \"Why does Semax carry a Pro-Gly-Pro extension?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Short peptides are rapidly degraded by peptidases. The Pro-Gly-Pro C-terminal extension was added to improve stability against that breakdown in experimental systems. Selank carries the same extension.\"}}, {\"@type\": \"Question\", \"name\": \"How does Semax differ from Selank?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Both are synthetic heptapeptides developed in Russia that end in Pro-Gly-Pro. Semax is derived from the ACTH(4–10) fragment and is researched mainly for neurotrophic signalling; Selank is derived from tuftsin and is researched mainly for GABAergic signalling.\"}}, {\"@type\": \"Question\", \"name\": \"How is purity verified?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Every batch is assayed by independent HPLC at Bioindustrial Services. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \/pages\/quality-standards.\"}}, {\"@type\": \"Question\", \"name\": \"How long does delivery take?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at \/pages\/delivery-process.\"}}, {\"@type\": \"Question\", \"name\": \"What is the returns policy?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Unopened vials in original condition may be returned under the conditions set out at \/pages\/return-refund-policy.\"}}]}\u003c\/script\u003e","brand":"Purist Peptides","offers":[{"title":"10mg","offer_id":51435019763935,"sku":"PP-SEMAX-10","price":49.95,"currency_code":"EUR","in_stock":false}],"url":"https:\/\/puristpeptides.nl\/products\/semax","provider":"Purist Peptides NL","version":"1.0","type":"link"}