Overview
In plain English
Semax is a synthetic seven-amino-acid peptide (Met-Glu-His-Phe-Pro-Gly-Pro) developed in Russia. It is an analogue of ACTH(4–10), a short fragment of the pituitary hormone adrenocorticotropin.
It is studied in preclinical and clinical research for its effects on BDNF expression and neurotrophic signalling, and in cognitive-function models. Strictly for laboratory research use. Not for human or veterinary consumption.
- What it isA synthetic heptapeptide analogue of the ACTH(4–10) fragment
- Mainly studied forBDNF expression, neurotrophic signalling, cognitive-function models
- Research protocolTo be published shortly. Contact us for details
How it works
What it actually does
Semax keeps the first four residues of the ACTH(4–10) fragment (Met-Glu-His-Phe) and ends in a Pro-Gly-Pro extension at the C-terminus.
That extension was added to improve stability: short peptides are broken down quickly by peptidases, and the Pro-Gly-Pro tail slows that breakdown.
Research interest centres on neurotrophic signalling, in particular the expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB.
The science in detail
Semax was developed in Russia as part of a research programme on short regulatory peptides derived from adrenocorticotropic hormone (ACTH). The ACTH(4–10) fragment had attracted interest because it retains activity in central nervous system models while lacking the adrenal-stimulating role of the full hormone.
The native fragment is short-lived in biological systems. Semax addresses this by retaining the N-terminal Met-Glu-His-Phe sequence and adding a C-terminal Pro-Gly-Pro extension, a motif chosen to improve resistance to enzymatic degradation. The result is a heptapeptide: Met-Glu-His-Phe-Pro-Gly-Pro.
The most cited mechanistic work concerns neurotrophins. Studies in rodents have reported changes in the expression of brain-derived neurotrophic factor (BDNF) and its high-affinity receptor TrkB in hippocampal tissue following Semax administration, and gene-expression studies have examined broader transcriptional responses in brain tissue.
Functional studies have used learning and memory paradigms in rodent cognitive-function models. As with many peptides from this research tradition, a large share of the literature comes from Russian research groups, and independent replication outside that setting is more limited.
Evidence
What the research shows
Built on a hormone fragment
Semax is an analogue of ACTH(4–10), a short fragment of adrenocorticotropic hormone.
Stabilised by Pro-Gly-Pro
A C-terminal Pro-Gly-Pro extension was added to slow enzymatic breakdown.
BDNF and TrkB signalling
Rodent studies report changes in BDNF and TrkB expression in brain tissue.
Studied in cognitive-function models
Learning and memory paradigms in rodents are a recurring research model.
Mixing & dosage
How to mix and dose it
Reconstitution and research protocol for this compound will be published here shortly. Contact us for details.
Strictly for laboratory research use. Not for human or veterinary consumption.
Questions
Frequently asked questions
What is Semax studied for?
Published work covers BDNF expression and neurotrophic signalling, gene-expression responses in brain tissue, and learning and memory performance in rodent cognitive-function models. Much of the literature originates from Russian research groups. Purist supplies the compound for laboratory research only.
How does Semax relate to ACTH?
Semax is an analogue of ACTH(4–10), a short fragment of adrenocorticotropic hormone. It keeps the fragment’s N-terminal Met-Glu-His-Phe sequence and replaces the remainder with a Pro-Gly-Pro extension.
Why does Semax carry a Pro-Gly-Pro extension?
Short peptides are rapidly degraded by peptidases. The Pro-Gly-Pro C-terminal extension was added to improve stability against that breakdown in experimental systems. Selank carries the same extension.
How does Semax differ from Selank?
Both are synthetic heptapeptides developed in Russia that end in Pro-Gly-Pro. Semax is derived from the ACTH(4–10) fragment and is researched mainly for neurotrophic signalling; Selank is derived from tuftsin and is researched mainly for GABAergic signalling.
How is purity verified?
Every batch is assayed by independent HPLC at Bioindustrial Services. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at Quality Standards.
How long does delivery take?
Orders are dispatched from the Netherlands with tracked courier delivery — 1–3 business days within the Netherlands, 2–5 business days to the rest of the EU. Current dispatch and transit windows are set out at Delivery Process.
What is the returns policy?
Unopened vials in original condition may be returned under the conditions set out at Refund Policy.
The Purist Research Standard
Precision-engineered peptides designed to maintain structural integrity under rigorous laboratory conditions.
Optimized Logistics & Fulfillment
Our logistics and fulfillment protocols are engineered to prioritize research stability.
≥99% Research-Grade Purity
Every compound is synthesized to exceed a 99% purity threshold.
Third-Party Laboratory Verified
We maintain total transparency through independent COA.
Precision Lyophilization Technology
Our advanced flash-freeze and vacuum-drying process.
Controlled Synthesis Environment
Produced in sterile, ISO-compliant facilities.
Targeted Research Utility
Engineered as reliable biological models.
Recommended Products
Essential Compounds for Precision Research: Top-Tier Peptides Verified for Structural Integrity.
Testimonials
Real feedback from customers who prioritize purity, precision, and uncompromising quality standards.
